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The University of California, Berkeley, Packard Instrument, PerkinElmer, FSM Technologies

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The University of California, Berkeley, has granted an exclusive license to nascent labeling company Lumiphore for US Patent No. 6,406,297, “Salicylamide-Lanthanide Complexes for Use as Luminescent Markers.” The patent, granted in June, covers fluorescence detection technology using lanthanide complexes. The technology was developed in the lab of UC Berkeley professor Kenneth Raymond, who co-founded Lumiphore along with his then-postdoc Stephane Petoud last year. The company said its technology offers higher signal-to-noise ratios and, consequently, higher sensitivity in comparison to current fluorescence detection systems. It also enables detection of four visible colors and several infrared colors, and resists photobleaching, according to Lumiphore.

Packard Instrument, now absorbed into PerkinElmer, has received US Patent No. 6,465,640, “Apparatus and method for calibration of a microarray scanning system.” The system describes a device that automatically calibrates both the detection system and the radiation source on the scanner through irradiation of the dilution spots, detecting the radiation produced by them, obtaining a series of brightness readings and analyzing the readings to obtain a fluorophore brightness. The detection system or the excitation radiation source is then adjusted to fit the brightness of the fluorophore.

FSM Technologies of Glasgow, UK, has obtained US Patent No. 6,465,640, “Method and device for purifying nucleic acids.” The patent describes methods for purifying nucleic acids from samples of whole cells, including whole blood samples. It also details a filter that is used in this filtration process.

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