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United States of America, Takara Bio, and Syntrix Biochip

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The United States of America of Washington, DC, has received US Patent No. 6,951,761, "Measurements of multiple molecules using a CryoArray." The patent claims CryoArrays that permit the analysis of samples — such as protein, nucleic acid, virus, or cell samples — in arrays that are prepared at low temperatures with minimal amounts of samples. CryoArrays are constructed as a block of columnar samples and can be sliced to provide a plurality of identical or substantially identical individual arrays, the patent claims. Also claimed are methods of making CryoArrays, devices for making CryoArrays, and kits. Methods for constructing classes of CryoArrays are provided, including protein-based CryoArrays, nucleic acid-based CryoArrays, cell-based CryoArrays, delivery CryoArrays, virus-based CryoArrays, and sample-based CryoArrays, are also claimed in the patent.


Takara Bio of Shiga, Japan, has received US Patent No. 6,951,722, "Method for amplifying nucleic acid sequence." The patent claims methods for amplifying a nucleic acid sequence characterized by effecting a DNA synthesis reaction in the presence of chimeric oligonucleotide primers. The methods described are a method for supplying a large amount of DNA amplification fragments; a method for amplifying a nucleic acid sequence by combining the above method with another nucleic acid sequence amplification method; a method for detecting a nucleic acid sequence for detecting or quantitating a microorganism such as a virus, a bacterium, a fungus or a yeast; and a method for detecting a DNA amplification fragment obtained by the above method in situ.


Syntrix Biochip of Auburn, Wash., has received US Patent No. 6,951,682, "Porous coatings bearing ligand arrays and use thereof." The patented invention provides coated articles comprising a substrate having a continuous porous coating of uniform thickness, where the coating comprises a gelled network of particles, and where the porous coating has two or more different compounds attached to it. Suitable particles may comprise one or more of carbon, activated carbon, fluorinated carbon, styrenedivinylbenzene copolymers, polystyrene, zeolites, oxides of antimony and oxides of metals present within Group III and Group IV of the periodic table, the patent claims. The gelled network of particles further comprises a polymer of a partially or substantially hydrolyzed metal alkoxide and substrates include glass and may comprise an adhesive layer. Attachment of compounds to the porous coating may be covalent or via adsorption, with or without the use of a linker. Preferred compounds include nucleobase polymers, peptides, and enalaprilat analogues.

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