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UAB Research Foundation, Nikon

UAB Research Foundation of Birmingham, Ala., has received US Patent No. 7,244,396, “Method for preparation of microarrays for screening of crystal growth conditions.” The patent claims a method of screening solution conditions suitable for the crystallization of macromolecules with a picogram to a microgram of protein using picoliter or nanoliter volumes. The method comprises: a) preparing a plurality of recipe solutions in milliliter volumes; b) aspirating protein and recipe solutions, respectively, from a plurality of wells; and c) dispensing the protein and recipe solutions into a plurality of wells, covering the combined protein and recipe solutions with oil, and maintaining the solution wells until crystallization or precipitation occurs.


Nikon has received US Patent No. 7,244,611, “Methods and devices for hybridization and binding assays using thermophoresis.” The patent describes an apparatus and method for performing hybridization or binding assays under thermophoretic conditions. Specifically, an apparatus is claimed that comprises a container designed to hold a solution of DNA and an array to which oligonucleotide probes are attached at discrete, known locations. Also claimed is a temperature control system for creating a temperature gradient in the solution sufficient to cause at least a portion of the solution to be warmer than the remainder of the solution. This condition then allows at least a portion of the DNA to move from the warmer portion of the solution to the cooler portion of the solution, causing at least a portion of the DNA to be driven onto or off of the surface of the array.

The Scan

Genome Sequences Reveal Range Mutations in Induced Pluripotent Stem Cells

Researchers in Nature Genetics detect somatic mutation variation across iPSCs generated from blood or skin fibroblast cell sources, along with selection for BCOR gene mutations.

Researchers Reprogram Plant Roots With Synthetic Genetic Circuit Strategy

Root gene expression was altered with the help of genetic circuits built around a series of synthetic transcriptional regulators in the Nicotiana benthamiana plant in a Science paper.

Infectious Disease Tracking Study Compares Genome Sequencing Approaches

Researchers in BMC Genomics see advantages for capture-based Illumina sequencing and amplicon-based sequencing on the Nanopore instrument, depending on the situation or samples available.

LINE-1 Linked to Premature Aging Conditions

Researchers report in Science Translational Medicine that the accumulation of LINE-1 RNA contributes to premature aging conditions and that symptoms can be improved by targeting them.