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Trinity College, Agilent Technologies, and Marligen Biosciences

Trinity College Dublin of Dublin, Ireland, has received US Patent No. 7,122,301, “Method of assaying cellular adhesion with a coated biochip.” The patent claims biological assays using various constructions of biochips to mirror in vivo situations. According to the patent’s abstract, the biochip includes a microchannel with a liquid outlet, a bubble release port, and a liquid outlet port with an associated bubble release. The assay assembly includes a syringe pump feeding the biochip, an inverted microscope, a digital camera, and recorder. A sample liquid containing cells in suspension is injected slowly through the biochip and the effect of the assay is recorded over a long period. A multiplicity of tests can be performed by coating the bore of the microchannel with various adhesion mediating proteins or chemoattractants, the abstract states.

Agilent Technologies has received US Patent No. 7,122,303, “Arrays comprising background features that provide for a measure of a non-specific binding and methods for using the same.” The patent describes methods for improved detection and analysis in nucleic acid hybridization assays. The methods provide a reliable estimation of background signal that derives primarily from nonspecific hybridization, and the invention is useful in chemical, biological, medical and diagnostic techniques, as well as for drug discovery, the patent’s abstract claims.

Marligen Biosciences of Ijamsville, Md., has received US Patent No. 7,122,317, “Multiplex method of detecting sequence-specific DNA binding proteins using detection duplexes comprising unmodified nucleic acid sequences as capture tags.” The patent claims compositions and methods for detecting and measuring DNA-binding proteins. The compositions and methods permit the simultaneous or near-simultaneous detection of multiple DNA-binding proteins in a multiplex or array format, and can be used to generate profiles of DNA binding activity by proteins, specifically, transcription factors, the patent’s abstract states. Multiple protein-DNA binding events in a single sample may be detected and quantified in a high-throughput format.

The Scan

Purnell Choppin Dies

Purnell Choppin, a virologist who led the Howard Hughes Medical Institute, has died at 91, according to the Washington Post.

Effectiveness May Decline, Data From Israel Suggests

The New York Times reports that new Israeli data suggests a decline in Pfizer-BioNTech SARS-CoV-2 vaccine effectiveness against Delta variant infection, though protection against severe disease remains high.

To See Future Risk

Slate looks into the use of polygenic risk scores in embryo screening.

PLOS Papers on Methicillin-Resistant Staphylococcus, Bone Marrow Smear Sequencing, More

In PLOS this week: genomic analysis of methicillin-resistant Staphylococcus pseudintermedius, archived bone marrow sequencing, and more.