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Thermo Fisher Scientific, Affymetrix, Mobidiag, Rosetta Biosoftware

Thermo Fisher Scientific this week launched the SuperChip AB, an agarose-based microarray substrate for proteomics and discovery.

Thermo Fisher said that agarose is an “economical, protein-friendly medium” that reduces the background noise that can interfere with signal detection of low-abundance proteins or peptides. The firm said SuperChip AB is an alternative to substrates that produce higher backgrounds, so low-expression molecules stand out.


Affymetrix last week launched the Cytogenetic Solution, a product for detecting chromosomal abnormalities associated with congenital diseases such as autism and mental retardation.
The Cytogenetic Solution includes Affy’s high-density SNP Array 6.0, which can detect both submicroscopic and large chromosomal abnormalities with clear definition of breakpoints; the firm’s Cytogenetics Copy Number Assay, which offers flexibility for low-and high-throughput users; and the Genotyping Console 2.1 software, which makes it easy to move from copy number and loss of heterozygosity data to results, the company said.
Francisco Cifuentes, senior product manager of molecular diagnostics, told BioArray News in an e-mail this week that the firm’s cytogenetic products are intended for research use only.

Mobidiag last week launched Prove-it Herpes, a microarray-based test that enables identification of eight different human herpesviruses in three hours.
The test is initially intended for research purposes. Mobidiag said it plans to gain European approval for use in clinical diagnostics later this year.

Rosetta Biosoftware said last week that version 7.1 of its Rosetta Resolver gene expression data analysis system, version 7.1, supports Affymetrix GeneChip Gene 1.0 ST arrays.
The Resolver system enables support of the arrays, including import and data analysis within the Resolver system and interaction with third-party programs, such as RMA, gcRMA, and Affymetrix PLIER, the company said.

The Scan

Enzyme Involved in Lipid Metabolism Linked to Mutational Signatures

In Nature Genetics, a Wellcome Sanger Institute-led team found that APOBEC1 may contribute to the development of the SBS2 and SBS13 mutational signatures in the small intestine.

Family Genetic Risk Score Linked to Diagnostic Trajectory in Psychiatric Disorders

Researchers in JAMA Psychiatry find ties between high or low family genetic risk scores and diagnostic stability or change in four major psychiatric disorders over time.

Study Questions Existence of Fetal Microbiome

A study appearing in Nature this week suggests that the reported fetal microbiome might be the result of sample contamination.

Fruit Fly Study Explores Gut Microbiome Effects on Circadian Rhythm

With gut microbiome and gene expression experiments, researchers in PNAS see signs that the microbiome contributes to circadian rhythm synchronicity and stability in fruit flies.