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Sydney Brenner, H. Robert Horvitz, John E. Sulston, Jeffrey White


Sydney Brenner, a professor at the Salk Institute for Biological Studies in La Jolla, Calif., shares this year’s Nobel Prize in medicine with H. Robert Horvitz and John E. Sulston, all awarded for their discoveries concerning genetic regulation of organ development and programmed cell death.

The laureates “have identified key genes regulating organ development and programmed cell death in worms and have shown that corresponding genes exist in higher species, including man,” said the Nobel committee in announcing the award last week in Sweden.

Brenner, whose pioneering work on Caenorhabditis elegans (C. elegans) established it as a novel experimental model organism, is director and principal scientific advisor for Lynx Therapeutics of Hayward, Calif., a company that engages in the discovery of gene expression patterns.

Jeffrey White leaves Agilent Technologies and joins NaPro BioTherapeutics of Boulder, Colo., as president of its newly-created genomics division, the company announced last week. White was the vice president and general manager of biochemistries and services for Agilent Technologies life sciences and chemical analysis group.

Prior to that, White was general manager of the chemistries and supplies division for the company, which split off from Hewlett-Packard three years ago. White worked in management and marketing for 15 years for Hewlett.

NaPro BioTherapeutics is a pharmaceutical company that seeks to develop or license novel pharmaceutical products.

The Scan

Genome Sequences Reveal Range Mutations in Induced Pluripotent Stem Cells

Researchers in Nature Genetics detect somatic mutation variation across iPSCs generated from blood or skin fibroblast cell sources, along with selection for BCOR gene mutations.

Researchers Reprogram Plant Roots With Synthetic Genetic Circuit Strategy

Root gene expression was altered with the help of genetic circuits built around a series of synthetic transcriptional regulators in the Nicotiana benthamiana plant in a Science paper.

Infectious Disease Tracking Study Compares Genome Sequencing Approaches

Researchers in BMC Genomics see advantages for capture-based Illumina sequencing and amplicon-based sequencing on the Nanopore instrument, depending on the situation or samples available.

LINE-1 Linked to Premature Aging Conditions

Researchers report in Science Translational Medicine that the accumulation of LINE-1 RNA contributes to premature aging conditions and that symptoms can be improved by targeting them.