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Suntory, Kaiwood Technology, Illumina

Suntory of Osaka, Japan, has received European Patent No. 1790733, “Screening method and screening apparatus using micro-chamber array.” The patent claims a method and apparatus for screening a microorganism or protein by using a micro-chamber array. According to the patent’s abstract, a protein or microorganism is screened by using a base plate containing micro-chambers arranged in the form of an array. The protein or microorganism is then detected by fluorescence produced by an enzyme reaction of the protein.

Kaiwood Technology of Tainan, Taiwan, has received US Patent No. 7,224,474, “Positioning method for biochip.” The patent claims a positioning method for biochip spotting. The method includes steps of: a) providing reference points on a biochip substrate; b) taking an image of the position of each reference point; c) calculating a first spotting position and performing spotting according to position information of the image of the positions; d) taking and recording the image of the spotted position; e) calculating to make feedback correction and setting up the next spotting position according to the position information of the image; and f) repeatedly performing step d and step e until all spotting is completed.

Illumina has received US Patent No. 7,226,734, “Multiplex decoding of array sensors with microspheres.” The patent describes a method of decoding an array so as to determine the location of a capture probe that has been randomly distributed on the array. The method includes steps of: a) providing an array with a plurality of distinct capture probes that are randomly distributed on the array; b) performing a hybridization step in which the capture probes are hybridized with a plurality of sets of decoder probes, where each set of decoder probes comprises a different label and each different label produces a different signal; c) detecting the signal produced by the hybridization step at a location on the array; d) performing a de-hybridization step; e) performing an additional hybridization step in which capture probes are hybridized with a plurality of sets of decoder probes; f) detecting the signal produced by the additional hybridization step; g) repeating steps d-f for a number of stages sufficient to generate a code comprising the sequence of signals detected at the location; and h) decoding the array with the code.

The Scan

Genome Sequences Reveal Range Mutations in Induced Pluripotent Stem Cells

Researchers in Nature Genetics detect somatic mutation variation across iPSCs generated from blood or skin fibroblast cell sources, along with selection for BCOR gene mutations.

Researchers Reprogram Plant Roots With Synthetic Genetic Circuit Strategy

Root gene expression was altered with the help of genetic circuits built around a series of synthetic transcriptional regulators in the Nicotiana benthamiana plant in a Science paper.

Infectious Disease Tracking Study Compares Genome Sequencing Approaches

Researchers in BMC Genomics see advantages for capture-based Illumina sequencing and amplicon-based sequencing on the Nanopore instrument, depending on the situation or samples available.

LINE-1 Linked to Premature Aging Conditions

Researchers report in Science Translational Medicine that the accumulation of LINE-1 RNA contributes to premature aging conditions and that symptoms can be improved by targeting them.