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SRU Biosystems, BioDiscovery, Beckman Coulter, The Regents of the University of California, Agilent Technologies

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SRU Biosystems of Woburn, Mass., has received US Patent No. 6,990,259, "Photonic crystal defect cavity biosensor." The patent claims a defect cavity photonic crystal biosensor that consists of an array of two-dimensional unit cells, each of the unit cells having a substrate and a multitude of raised portions arranged in a regular repeating pattern such that the raised portions are separated from each other by adjacent void portions.


BioDiscovery of El Segundo, Calif., has received US Patent No. 6,990,221, "Automated DNA array image segmentation and analysis." The patent describes a segmentation method for capturing and arranging an image that includes a plurality of spaced DNA spot images corresponding to a plurality of DNA spots. The image's information includes image intensity level information corresponding to the DNA spots, the patent states, and the frame is stored in a memory device and a set of image information within the frame where a set of the DNA spot images is selected. A grid including a plurality of spaced grid points corresponding to the selected DNA spot images is generated, so that each grid point includes position information indicating the position of the grid point within said frame. A display method displays image information corresponding to a plurality of DNA spot images of at least one DNA spot, and the image information including image characteristic values including background and signal intensity levels, according to the patent.


Beckman Coulter of Fullerton, Calif., received US Patent No. 6,989,175, "Acyl fluoride activation of carboxysilyl-coated glass substrates." A method for the acyl fluoride activation of a carboxysilyl-coated glass is claimed. The method includes providing a glass substrate having a surface with at least one pendant carboxysilyl linker comprising a carboxyl group, and activating without etching the surface of the glass by converting the carboxyl group into an acyl fluoride group. A substrate for the covalent immobilization of nucleophile-containing species is also provided. The substrate comprises a glass having a surface with a pendant carboxysilyl linker activated by acyl fluoride without etching the surface of the glass, according to the patent. The invention also provides a microarray formed on a glass surface activated with acyl fluorides without etching.


The Regents of the University of California of Oakland, Calif., have received US Patent No. 6,989,237, "Capillary array and related methods." The patent claims methods and devices for detecting the presence of one or more target analytes in a sample employing a channel where one or more binding partners for each target analyte are affixed. Assays are carried out by transporting the sample through the channel to each successive binding partner so that target analyte present in the sample binds to its binding partner.


Agilent Technologies of Palo Alto, Calif., has received US Patent No. 6,989,267, "Methods of making microarrays with substrate surfaces having covalently bound polyelectrolyte films." The patent claims methods for associating a polyelectrolyte coating or film to a substrate surface, as well as polyelectrolyte-coated substrates. According to the patent, substrate surfaces are coated with a polyelectrolyte, and the coated substrate surfaces are then treated with a bifunctional molecule under conditions sufficient to stably associate the film to the array surface. The patent claims the methods can be used in different applications, including the production of microarrays.

The Scan

Lung Cancer Response to Checkpoint Inhibitors Reflected in Circulating Tumor DNA

In non-small cell lung cancer patients, researchers find in JCO Precision Oncology that survival benefits after immune checkpoint blockade coincide with a dip in ctDNA levels.

Study Reviews Family, Provider Responses to Rapid Whole-Genome Sequencing Follow-up

Investigators identified in the European Journal of Human Genetics variable follow-up practices after rapid whole-genome sequencing.

BMI-Related Variants Show Age-Related Stability in UK Biobank Participants

Researchers followed body mass index variant stability with genomic structural equation modeling and genome-wide association studies of 40- to 72-year olds in PLOS Genetics.

Genome Sequences Reveal Range Mutations in Induced Pluripotent Stem Cells

Researchers in Nature Genetics detect somatic mutation variation across iPSCs generated from blood or skin fibroblast cell sources, along with selection for BCOR gene mutations.