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Sequenom, GeneMachines, Aclara Bioscience

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High-throughput SNP genotyping company Sequenom has developed a gene expression application for its industrial-scale MassArray system. The company said its system is able to absolutely quantify gene expression, from the level of a few molecules to millions of copies, and that it can determine allele-specific expression and perform expression analysis of splice variants. The system has the capacity to perform this analysis on several hundred genes in several hundred samples per day, according to the company.

GeneMachines has introduced the second-generation version of its PolyPlex oligonucleotide synthe- sizer. The Polyplex can synthesize up to one micromol of oligos, has eight amidite reagent positions, and can accommodate a range of bottle sizes, the company said.

Aclara Bioscience has debuted a new eTag Assay System. The system uses Aclara’s eTag reporters for multiplex analysis of tens to hundreds of genes, proteins, or cell surface antigens from a single sample, the company said. The assay is solution-phase, and uses microwell plates. The eTag reporters, released during molecular binding events in the sample, are electrophoretically distinct and are designed for simultaneous quantitation of genes and proteins from the same cell lysate, according to the company. The company is marketing the eTag assays under an eTag expert access program, which offers licenses for research use to the system.

The Scan

Genome Sequences Reveal Range Mutations in Induced Pluripotent Stem Cells

Researchers in Nature Genetics detect somatic mutation variation across iPSCs generated from blood or skin fibroblast cell sources, along with selection for BCOR gene mutations.

Researchers Reprogram Plant Roots With Synthetic Genetic Circuit Strategy

Root gene expression was altered with the help of genetic circuits built around a series of synthetic transcriptional regulators in the Nicotiana benthamiana plant in a Science paper.

Infectious Disease Tracking Study Compares Genome Sequencing Approaches

Researchers in BMC Genomics see advantages for capture-based Illumina sequencing and amplicon-based sequencing on the Nanopore instrument, depending on the situation or samples available.

LINE-1 Linked to Premature Aging Conditions

Researchers report in Science Translational Medicine that the accumulation of LINE-1 RNA contributes to premature aging conditions and that symptoms can be improved by targeting them.