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Sequenom, GeneMachines, Aclara Bioscience


High-throughput SNP genotyping company Sequenom has developed a gene expression application for its industrial-scale MassArray system. The company said its system is able to absolutely quantify gene expression, from the level of a few molecules to millions of copies, and that it can determine allele-specific expression and perform expression analysis of splice variants. The system has the capacity to perform this analysis on several hundred genes in several hundred samples per day, according to the company.

GeneMachines has introduced the second-generation version of its PolyPlex oligonucleotide synthe- sizer. The Polyplex can synthesize up to one micromol of oligos, has eight amidite reagent positions, and can accommodate a range of bottle sizes, the company said.

Aclara Bioscience has debuted a new eTag Assay System. The system uses Aclara’s eTag reporters for multiplex analysis of tens to hundreds of genes, proteins, or cell surface antigens from a single sample, the company said. The assay is solution-phase, and uses microwell plates. The eTag reporters, released during molecular binding events in the sample, are electrophoretically distinct and are designed for simultaneous quantitation of genes and proteins from the same cell lysate, according to the company. The company is marketing the eTag assays under an eTag expert access program, which offers licenses for research use to the system.

The Scan

Driving Malaria-Carrying Mosquitoes Down

Researchers from the UK and Italy have tested a gene drive for mosquitoes to limit the spread of malaria, NPR reports.

Office Space to Lab Space

The New York Times writes that some empty office spaces are transforming into lab spaces.

Prion Pause to Investigate

Science reports that a moratorium on prion research has been imposed at French public research institutions.

Genome Research Papers on Gut Microbe Antibiotic Response, Single-Cell RNA-Seq Clues to Metabolism, More

In Genome Research this week: gut microbial response to antibiotic treatment, approach to gauge metabolic features from single-cell RNA sequencing, and more.