Siemens of Munich, Germany, and Nanogen of San Diego have received US Patent No. 7,315,784, “Network for evaluating data obtained in a biochip measurement device.” The patent claims a method and a network for evaluating medical data in a clinical study where biochips containing patient samples with multiple biomolecular markers are tested in a number of point-of-care test devices at various sites. According to the patent abstract, each test of each biochip sample produces a diagnostic result, which is then entered into the electronic patient record for the patient who produced the sample. A follow-up examination is conducted for each patient, and the results of the follow-up examination are also entered into that patient's electronic patient record. The follow-up results indicate whether the diagnostic test result was a false positive, a false negative or correct. The follow-up data and the original diagnostic results from all point-of-care sites are electronically transmitted to a remote server, which has access to an expert system that uses the test results and the follow-up data to automatically devise a measurement protocol for a selected pathology.
Sapporo Breweries, Sony, Affymetrix, University of California, National Cancer Center, Osmetech, BioArray Solutions, Siemens, Nanogen
Sapporo Breweries of Tokyo has received European Patent No. 1865057, “DNA array and method for analysis of gene expression of brewing yeast.” The method does not require information about the genomic sequence of the yeast and can be used to control its fermentation process, the patent’s abstract states. Also claimed is a DNA array for use in the method for gene expression analysis that includes a substrate, a plurality of spots provided on the substrate, and a plasmid containing a genomic DNA fragment of brewing yeast, which is bound to each of the spots.
Sony of Tokyo has received European Patent No. 1865322, “Bioreaction execution apparatus, method of bioreaction execution, DNA chip, information processing unit, method of information processing, program and recording medium.” The patent claims a bioreaction execution apparatus where an electric field is generated in a flow channel on a DNA chip in which a solution containing a target gene is dropped so as to attain electrophoresis of the target gene. In addition, a method of bioreaction execution, a DNA chip, an information processing unit, a method of information processing, and a program and recording medium are also claimed.
Affymetrix has received US Patent No. 7,312,035, “Methods of genetic analysis of yeast.” The patent describes arrays of oligonucleotide probes that are complementary to S. cerevisisae and S. pombe genes. The arrays may be used to measure the expression levels of a plurality of genes at the same time.
Affymetrix has also received US Patent No. 7,314,595, “High-throughput microarray spotting system and method.” A system is described for automatic retrieval of microplates from a carousel. The system includes: a) an effector arm that retrieves a selected microplate from the carousel; b) a microplate retainer that receives the selected microplate from the effector arm; and c) a controller that directs the effector arm to the carousel for retrieval of the selected microplate and directs the effector arm to the microplate retainer so that it may receive the selected microplate. The carousel may revolve around a vertical axis. A system also is described for washing depositing elements used to spot biological materials on a substrate. Graphical user interfaces also are described for enabling a user to determine which microplates will be used to provide biological probe materials, and in what patterns those probe materials should be deposited on the substrate. The interfaces enable the user to place multiple fractions of biological materials on a same location on a substrate, according to the patent abstract.
Affymetrix has also received US Patent No. 7,314,750, “Addressable oligonucleotide array of the rat genome.” The patent claims nucleic acid sequences that are complementary to a wide variety of rat genes. In one embodiment, the nucleic acid sequences provided are present as an array of probes that may be used to measure gene expression of at least 20,000 rat genes. The described array can be used in chemistry, biology, medicine, and medical diagnostics.
The University of California of Oakland, Calif., has received US Patent No. 7,312,068, “Capillary pins for high-efficiency microarray printing device.” The patent claims improved components, including array pins, print heads, and substrate plates, for microarray printing devices. In one embodiment, the patent claims a microarray print head that includes glass or quartz-spotting capillaries in a support that maintains a fixed spacing between the spotting capillaries and that permits the spotting capillaries to move in a direction parallel to the long axis of the capillaries.
The National Cancer Center of Seoul, Korea, has received US Patent No. 7,312,070, “β-catenin oligonucleotide microchip and method for detecting β-catenin mutations employing same.” The patent describes a β-catenin oligonucleotide array for detecting mutations in the mutational hot spot regions of the β-catenin gene. A manufacturing process and a method for detecting the β-catenin mutation are also claimed, where specific oligonucleotides are selectively designed to detect various missense mutations and in-frame deletion at the mutational hot spots of the β-catenin gene. The β-catenin oligo chip can be used in studies to detect β-catenin mutations and unravel the signal transduction mechanism and tumorigenesis related to the β-catenin gene.
Osmetech, formerly Clinical Micro Sensors, of Pasadena, Calif., has received US Patent No. 7,312,087, “Devices and methods for biochip multiplexing.” The patent describes devices and methods that allow for simultaneous multiple biochip analysis. The method of analyzing the biochips includes inserting a first biochip into a first station of an analysis device and inserting a second biochip into a second station of the analysis device, where each of the first and second biochips include a substrate containing an array of detection electrodes. Each electrode in turn includes a different capture-binding ligand, a different target analyte, a label, and a plurality of electrical contracts. The method then calls for detecting current as an indication of the presence of the labels on the first biochip, and detecting current as an indication of the presence of the labels on the first second biochip. The devices and method may be used with multiple cartridges including arrays, such as nucleic acid arrays, and allow for high-throughput analysis of samples.
BioArray Solutions of Warren, NJ, has received US Patent No. 7,315,637, “Image processing and analysis of array data.” The patent claims methods of processing images by aligning and orienting grids from a fluorescent array of signal sources by linking nearest neighbor sources to form a hexagon, and then using the hexagon lines for alignment and orientation of the grid. Also described are methods and algorithms for aligning images with a grid and correcting for signal beads that are smaller than a grid field and the shift in a grid field. These methods can be used where the signal sources are fluorescent images from a microarray.