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New Product Watch: Dec 2, 2008

Roche NimbleGen last month launched its Human CGH 12x135K Whole-Genome Tiling version 2.0 array for the analysis of DNA copy number variation.
The array allows the analysis of 12 independent sample pairs on a single microarray slide, each with 135,000 oligonucleotide probes. The chips are manufactured on Roche NimbleGen's new 2.1-million feature HD2 platform. NimbleGen previously made available 385K and 4x72K arrays for CGH.
To support the new CGH arrays, NimbleGen also launched NimbleScan version 2.5, software that includes an experimental metrics report and enhanced analysis features for the arrays.

The Scan

Genome Sequences Reveal Range Mutations in Induced Pluripotent Stem Cells

Researchers in Nature Genetics detect somatic mutation variation across iPSCs generated from blood or skin fibroblast cell sources, along with selection for BCOR gene mutations.

Researchers Reprogram Plant Roots With Synthetic Genetic Circuit Strategy

Root gene expression was altered with the help of genetic circuits built around a series of synthetic transcriptional regulators in the Nicotiana benthamiana plant in a Science paper.

Infectious Disease Tracking Study Compares Genome Sequencing Approaches

Researchers in BMC Genomics see advantages for capture-based Illumina sequencing and amplicon-based sequencing on the Nanopore instrument, depending on the situation or samples available.

LINE-1 Linked to Premature Aging Conditions

Researchers report in Science Translational Medicine that the accumulation of LINE-1 RNA contributes to premature aging conditions and that symptoms can be improved by targeting them.