Researchers Find Disease Risk Predictions 'Differ Substantially' for Arrays and Sequencing | GenomeWeb

Researchers using commercial SNP genotyping arrays should be wary of using their results to make predictions about an individual's genetic risk of developing certain diseases, according to a new study.

The study, from scientists at Stanford University, found that risk predictions derived from next-generation sequencing differ substantially from those obtained from genotyping arrays for several non-monogenic diseases. At the same time, high-density genotyping arrays may give results that are identical with sequencing results for many diseases.

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