Researchers Catalog Loss-of-Function Variants in Protein-Coding Genes | GenomeWeb

By Andrea Anderson

NEW YORK (GenomeWeb News) – A Wellcome Trust Sanger Institute and Yale University-led team has sifted through data from three 1000 Genomes Project pilot efforts to find a set of authentic loss-of-function variants in the human genome.

The work offers a peek at the types of genes typically affected by these changes and clues for distinguishing disease-related variants from those that are more harmless.

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