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Research Corporation Technologies, ViaLogy, Fuji Photo Film, Picoliter, Affymetrix


Research Corporation Technologies of Tucson, Ariz., received US Patent No. 6,670,193, “Fluorescent nucleoside analogs and combinatorial fluorophore arrays comprising same.” The patent provides for fluorescent nucleoside analogs that comprise a fluorescent cyclic compound joined to a carbon of a sugar molecule.

ViaLogy of Alta Deena, Calif., received US Patent No. 6,671,625, “Method and system for signal detection in arrayed instrumentation based on quantum resonance interferometry.” The patent covers a system for determining the presence of specific hybridization expression within an output pattern generated from a digitized image of a biological sample applied to an arrayed platform. Signal processing via quantum resonance interferometry or stochastic resonance interferometry is used to amplify signals associated with the biological sample having an intensity lower than the intensity of signals associated with noise so that they may be clearly distinguished from background noise.

Fuji Photo Film of Japan received US Patent No. 6,670,198, “Test piece and system for reading out image information from the test piece.” The patent covers a technology for use in biological analyses of different known specific binding substances disposed in predetermined positions on a substrate.

Picoliter received US Patent No. 6,666,541, “Acoustic ejection of fluids from a plurality of reservoirs.” The patent covers a system for the acoustic ejection of fluid droplets from fluid-containing reservoirs.

Affymetrix received US Patent No. 6,667,394, “Printing oligonucleotide arrays.” The patent covers a method for selectively applying a print material onto a substrate.


The Scan

Team Tracks Down Potential Blood Plasma Markers Linked to Heart Failure in Atrial Fibrillation Patients

Researchers in BMC Genomics found 10 differentially expressed proteins or metabolites that marked atrial fibrillation with heart failure cases.

Study Points to Synonymous Mutation Effects on E. Coli Enzyme Activity

Researchers in Nature Chemistry saw signs of enzyme activity shifts in the presence of synonymous mutations in a multiscale modeling analysis of three Escherichia coli genes.

Team Outlines Paternal Sample-Free Single-Gene Approach for Non-Invasive Prenatal Screening

With data for nearly 9,200 pregnant individuals, researchers in Genetics in Medicine demonstrate the feasibility of their carrier screening and reflex single-gene non-invasive prenatal screening approach.

Germline-Targeting HIV Vaccine Shows Promise in Phase I Trial

A National Institutes of Health-led team reports in Science that a broadly neutralizing antibody HIV vaccine induced bnAb precursors in 97 percent of those given the vaccine.