The Regents of the University of California, of Oakland, Calif., has received US Patent No. 6,893,837, "Frozen tissue microarray technology for analysis RNA, DNA, and proteins." The patented invention builds upon existing tissue microarray technology by using frozen tissues embedded in tissue-embedding compound as donor samples and arraying the specimens into a recipient block comprising of tissue embedding compound. The tissue is not fixed prior to embedding, and sections from the array are evaluated without fixation according to the appropriate methodology used to analyze a specific gene at the DNA, RNA, and/or protein levels. Unlike paraffin tissue arrays which can be problematic for immunohistochemistry and for RNA in situ hybridization analyses, the described methods allow evaluation by each technique and uniform fixation across the array panel. The disclosed arrays work well for DNA, RNA, and protein analyses, and have significant qualitative and quantitative advantages over existing methods.
SII Nano Technology of Chiba, Japan, has received US Patent No. 6,893,824, "Gene detection system, gene detection device comprising same, detection method, and gene detecting chip." The patent covers a gene detection system for detecting a target gene upon hybridization with probes. The probes in the hybridization experiment consist of a probe-immobilizing support on which a probe is immobilized, as well as heating and cooling means on which the probe is immobilized, whereby genes can be rapidly detected with high sensitivity through hybridization.
Seiko Epson of Tokyo, Japan has received US Patent No. 6,893,104, "Head driving device of liquid ejecting apparatus and method of discharging charge on charge element thereof." The patented head driving device includes a liquid ejecting head formed with a nozzle orifice from which a liquid droplet is ejected, a driving signal generator generating a driving signal, a pressure generating element applying pressure to liquid based on the driving signal for ejecting the liquid droplet, a charge element charged at a reference voltage lower than a drive voltage for driving the pressure generating element, and applying a bias voltage to the pressure generating element, and a discharge circuit discharging a charge on the charge element to a ground when a voltage of the charge on the charge element is equal to or higher than a first voltage which is higher than the bias voltage. The described liquid ejecting device is used as a record apparatus used with an image record apparatus, a color material ejecting apparatus used for manufacturing a color filter of a liquid crystal display, an electrode material (conductive paste) ejecting apparatus used for electrode formation of an organic EL display, a face light emitting display, and a bioorganic substance ejecting apparatus used for biochip manufacturing.
Commissariat a l'Energie Atomique of Paris, France, and BioMerieux of Marcy L'Etoile, France, have received US Patent No. 6,893,876, "Enhancing surface-generated fluorescence signal emitted by a sample." The patent describes a device and process for the amplification of fluorescence emitted by an areal sample. The patented device supports the transmission of a fluorescence signal and is configured to support the areal sample and a thin layer interposed between the support and the areal sample. The thin layer has a refractive index greater than the refractive index of the support and than the refractive index of a medium flooding the areal sample during a fluorescence measurement. The thickness of the thin layer is chosen so that the thin layer transmits all or part of the fluorescence signal which is measured after passing through the support. The invention includes a biochip for reading by fluorescence, the biochip comprising of a support configured to transmit all or part of a fluorescence signal emitted in response to an excitation signal and configured to support a plurality of areal samples constituting as many recognition zones. The recognition molecules on the biochip may be oligonucleotides, polynucleotides, proteins, lectins or any other system of the ligand-receptor type. In particular the recognition molecules may be comprised of DNA or RNA fragments.