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Randox Laboratories, Fluidigm, Affymetrix, Applied Biosystems, Roche Diagnostics

Randox Laboratories has received European Patent No. 1912731, “Manufacture of array chips.” The patent claims a method of manufacturing an array chip by: a) depositing at least one ligand onto the active surface of a wafer substrate, having at least one scribe line, the active surface being the reverse of the surface comprising the at least one scribe line; b) detecting the ligand in relation to the at least one scribe line; and c) breaking the wafer substrate along the at least one scribe line, to produce at least one array chip.

Fluidigm of South San Francisco, Calif., has received US Patent No. 7,368,163, “Polymer surface modification.” The patent describes a surface-modified polymer comprising a surface that is covalently bonded to a surface modifying compound. Formation of the covalent bond between the polymer and the surface-modifying compound is achieved by a reaction between an intrinsic functional group that is present in the polymer and the functional group of the surface-modifying compound. By using a polymer having an intrinsic functional group, a separate surface activation step is avoided.

Affymetrix has received US Patent No. 7,368,242, “Method and kits for multiplex hybridization assays.” The patent claims a method for genotyping interfering polymorphic loci in a target polynucleotide, such as a strand of genomic DNA, in a multiplex hybridization-based assay. The patent also provides nucleic acid standards for validating the performance of such hybridization-based assays. In one aspect, the method is carried out by providing for each interfering polymorphic locus one or more probes so that at least one probe is capable of forming a perfectly matched duplex at the locus regardless of the characteristic sequence of an adjacent polymorphism.

Applied Biosystems has received US Patent No. 7,368,296, “Solid phases optimized for chemiluminescent detection.” The patent describes a solid support for chemiluminescent assays. The solid support includes a plurality of probes covalently or physically attached to the support surface and a chemiluminescent enhancing moiety incorporated onto the surface or into the bulk of the support. A method and a kit for conducting chemiluminescent assays using the solid supports are also provided. The kit comprises a dioxetane substrate, a biopolymer probe-enzyme complex, and a solid support. The solid support can be an azlactone functional polymer layer adjacent to a cationic microgel layer; a porous polyamide functional layer adjacent to a cationic microgel layer; or a quaternized azlactone functional polymer layer. According to the patent, the support can be used in array-based assays.

Roche Diagnostics has received US Patent No. 7,369,227, “Imaging fluorescence signals using telecentricity.” The patent claims a device for the parallel imaging of fluorescence intensities at a plurality of sites as a measure for DNA hybridization. More specifically, the device can be used to image multiplex real-time PCR or to read the results of assays that include several DNA microarrays.

The Scan

Researchers Develop Polygenic Risk Scores for Dozens of Disease-Related Exposures

With genetic data from two large population cohorts and summary statistics from prior genome-wide association studies, researchers came up with 27 exposure polygenic risk scores in the American Journal of Human Genetics.

US Survey Data Suggests Ancestry Testing Leads Way in Awareness, Use of Genetic Testing Awareness

Although roughly three-quarters of surveyed individuals in a Genetics in Medicine study reported awareness of genetic testing, use of such tests was lower and varied with income, ancestry, and disease history.

Coral Genome Leads to Alternative Amino Acid Pathway Found in Other Non-Model Animals

An alternative cysteine biosynthesis pathway unearthed in the Acropora loripes genome subsequently turned up in sequences from non-mammalian, -nematode, or -arthropod animals, researchers report in Science Advances.

Mosquitos Genetically Modified to Prevent Malaria Spread

A gene drive approach could be used to render mosquitos unable to spread malaria, researchers report in Science Advances.