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Quantum Logic Devices, Micromet, BioMachines, Deutsches Krebsforschungszentrum, UT-Battelle, Nanosphere of Northbrook, Whitehead Institute, Dana-Farber Cancer Institute, University of California, MiniMed, Affymetrix


Quantum Logic Devices of Austin, Texas, received US Patent No. 6,673,717, “Methods for fabricating nanopores for single-electron devices.” The patent describes nanopores for single-electron devices that may be used as templates for placing nanoparticles at a desired location in devices.

Micromet of Martinsried, Germany, received US Patent No. 6,673,541, “DNA amplification of a single cell.” The patent covers a method for the amplification of DNA, particularly useful for the amplification of the DNA or the whole genome of a single cell, or chromosomes or fragments.

BioMachines of Morrisville, NC, received US Patent No. 6,673,315, “Method and apparatus for accessing a site on a biological substrate.” The patented method allows the location of materials deposited on a substrate to be identified, and communicated with precision.

Deutsches Krebsforschungszentrum of Heidelberg, Germany, received US Patent No. 6,673,544, “Method for the light-controlled synthesis of biochips.” The patent describes a method for the photolithographic synthesis of biochips whereby the irradiation step that is common in the photolithographic chip synthesis is carried out in the presence of a base.

UT-Battelle and the University of Tennessee Research Corporation received US Patent No. 6,673,596, “In vivo biosensor apparatus and method of use.” The patent describes a bioluminescent bioreporter integrated circuit devices that detect selected analytes in fluids when implanted in the body of an animal.

Nanosphere of Northbrook, Ill., received US Patent No. 6,673,548, “Nanoparticles having oligonucleotides attached thereto and uses therefore.” The patent provides methods of detecting a nucleic acid with one or more types of particles having oligonucleotides attached.

The Whitehead Institute for Biomedical Research and the Dana-Farber Cancer Institute received US Patent No. 6,647,341, “Methods for classifying samples and ascertaining previously unknown classes.” The patent covers methods and apparatus for classifying or predicting the classes for samples based on gene expression. Also described are methods and apparatus for ascertaining or discovering new, previously unknown classes based on gene expression.

The Regents of the University of California and MiniMed of Sylmar, Calif., received US Patent No. 6,673,625, “Saccharide sensing molecules having enhanced fluorescent properties.” The patent covers formulas for fluorescent compounds uniquely suited for use in sensors of analytes such as saccharides.

Affymetrix received US Patent No. 6,673,579, “Methods and compositions for multiplex amplification of nucleic acids.” The patent covers a method for predetermining ratios of primer pairs present in a single reaction vessel for an equimolar yield of products. The primers may desirably be for p53 gene sequences.

The company also received US Patent No. 6,670,122, “Method for detecting transcription templates.” The patent provides methods for detecting and for determining the template strand of a genomic DNA.

The Scan

Study Points to Tuberculosis Protection by Gaucher Disease Mutation

A mutation linked to Gaucher disease in the Ashkenazi Jewish population appears to boost Mycobacterium tuberculosis resistance in a zebrafish model of the lysosomal storage condition, a new PNAS study finds.

SpliceVault Portal Provides Look at RNA Splicing Changes Linked to Genetic Variants

The portal, described in Nature Genetics, houses variant-related messenger RNA splicing insights drawn from RNA sequencing data in nearly 335,700 samples — a set known as the 300K-RNA resource.

Automated Sequencing Pipeline Appears to Allow Rapid SARS-CoV-2 Lineage Detection in Nevada Study

Researchers in the Journal of Molecular Diagnostics describe and assess a Clear Labs Dx automated workflow, sequencing, and bioinformatic analysis method for quickly identifying SARS-CoV-2 lineages.

UK Team Presents Genetic, Epigenetic Sequencing Method

Using enzymatic DNA preparation steps, researchers in Nature Biotechnology develop a strategy for sequencing DNA, along with 5-methylcytosine and 5-hydroxymethylcytosine, on existing sequencers.