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In Print: Last Week's Microarray Papers of Note: Jul 22, 2014

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Vaccine-associated varicella and rubella infections in severe combined immunodeficiency with isolated CD4 lymphocytopenia and mutations in IL7R detected by tandem whole exome sequencing and chromosomal microarray.
Clin Exp Immunol. 2014 Jul 21. [Epub ahead of print]
Bayer D, et al.

The authors describe a female infant who presented with disseminated vaccine-acquired varicella and vaccine-acquired rubella infections at 13 months of age. A combination of whole exome sequencing and custom-designed chromosomal microarray with exon coverage of primary immunodeficiency genes detected compound heterozygous mutations within the IL7R gene.


Linkage disequilibrium over short physical distances measured in sheep using a high-density SNP chip.
Anim Genet. 2014 Jul 17. [Epub ahead of print]
Kijas J, et al.

The authors used Illumina ovine SNP50 and HD Beadchips to study the persistence of linkage disequilibrium in diverse sheep breeds. The determined that LD varies considerably between sheep breeds, and that sheep appear to contain generally lower levels of LD than do other domestic species, reflecting aspects of their past population history.


Genome-wide microarray analysis of Atlantic cod (Gadus morhua) oocyte and embryo.
BMC Genomics. 2014 Jul 14;15(1):594.
Kugor A, et al.

The authors report a study of early Atlantic cod development that used a genome-wide oligonucleotide microarray to examine the composition and putative roles of polyadenylated transcripts. Transcriptome profiling of the early stages in Atlantic cod revealed the presence of transcripts involved in patterning and development of tissues and organs long before activation of the zygotic genome.

The Scan

Interfering With Invasive Mussels

The Chicago Tribune reports that researchers are studying whether RNA interference- or CRISPR-based approaches can combat invasive freshwater mussels.

Participation Analysis

A new study finds that women tend to participate less at scientific meetings but that some changes can lead to increased involvement, the Guardian reports.

Right Whales' Decline

A research study plans to use genetic analysis to gain insight into population decline among North American right whales, according to CBC.

Science Papers Tie Rare Mutations to Short Stature, Immunodeficiency; Present Single-Cell Transcriptomics Map

In Science this week: pair of mutations in one gene uncovered in brothers with short stature and immunodeficiency, and more.