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In Print: Last Week's Microarray Papers of Note: Jul 15, 2014


Genomic imbalance in products of conception: single-nucleotide polymorphism chromosomal microarray analysis.
Obstet Gynecol. 2014 Jul 7. [Epub ahead of print]
Levy B, et al.

The authors set out to report the full cohort of identifiable anomalies, regardless of known clinical significance, in a large-scale cohort of postmiscarriage products-of-conception samples using a high-resolution SNP microarray platform. They determined that chromosomal microarray analysis of products-of-conception specimens yields a high diagnostic return and that using SNPs extends the scope of detectable genomic abnormalities and facilitates the reporting of true fetal results.

A genome-wide association study of immune response traits in Canadian Holstein cattle.
BMC Genomics. 2014 Jul 4;15(1):559.
Thompson-Crispi K, et al.

The authors performed genome-wide association studies to determine differences in genetic profiles among Holstein cows classified as High or Low for antibody-mediated and cell-mediated immune responses. They genotyped 303 cows using the Illumina Bovine SNP50 BeadChip, and found 186 SNPs, mostly on chromosome 23, that were significantly associated with AMIR, with 21 SNP markers significant for CMIR. They believe it may be feasible to include immune response in genomic breeding indices as an approach to improving animal health.

Are copy number variants associated with adolescent idiopathic scoliosis?
Clin Orthop Relat Res. 2014 Jul 9. [Epub ahead of print]
Buchan J, et al.

The authors used the Affymetrix Genome-wide Human SNP Array 6.0 to evaluate the frequency of recurrent copy number rearrangements, chromosome aneuploidy, and rare copy number variants in patients with adolescent idiopathic scoliosis.

The Scan

Positive Framing of Genetic Studies Can Spark Mistrust Among Underrepresented Groups

Researchers in Human Genetics and Genomics Advances report that how researchers describe genomic studies may alienate potential participants.

Small Study of Gene Editing to Treat Sickle Cell Disease

In a Novartis-sponsored study in the New England Journal of Medicine, researchers found that a CRISPR-Cas9-based treatment targeting promoters of genes encoding fetal hemoglobin could reduce disease symptoms.

Gut Microbiome Changes Appear in Infants Before They Develop Eczema, Study Finds

Researchers report in mSystems that infants experienced an enrichment in Clostridium sensu stricto 1 and Finegoldia and a depletion of Bacteroides before developing eczema.

Acute Myeloid Leukemia Treatment Specificity Enhanced With Stem Cell Editing

A study in Nature suggests epitope editing in donor stem cells prior to bone marrow transplants can stave off toxicity when targeting acute myeloid leukemia with immunotherapy.