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In Print: Last Week's Microarray Papers of Note: Jul 15, 2014

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Genomic imbalance in products of conception: single-nucleotide polymorphism chromosomal microarray analysis.
Obstet Gynecol. 2014 Jul 7. [Epub ahead of print]
Levy B, et al.

The authors set out to report the full cohort of identifiable anomalies, regardless of known clinical significance, in a large-scale cohort of postmiscarriage products-of-conception samples using a high-resolution SNP microarray platform. They determined that chromosomal microarray analysis of products-of-conception specimens yields a high diagnostic return and that using SNPs extends the scope of detectable genomic abnormalities and facilitates the reporting of true fetal results.


A genome-wide association study of immune response traits in Canadian Holstein cattle.
BMC Genomics. 2014 Jul 4;15(1):559.
Thompson-Crispi K, et al.

The authors performed genome-wide association studies to determine differences in genetic profiles among Holstein cows classified as High or Low for antibody-mediated and cell-mediated immune responses. They genotyped 303 cows using the Illumina Bovine SNP50 BeadChip, and found 186 SNPs, mostly on chromosome 23, that were significantly associated with AMIR, with 21 SNP markers significant for CMIR. They believe it may be feasible to include immune response in genomic breeding indices as an approach to improving animal health.


Are copy number variants associated with adolescent idiopathic scoliosis?
Clin Orthop Relat Res. 2014 Jul 9. [Epub ahead of print]
Buchan J, et al.

The authors used the Affymetrix Genome-wide Human SNP Array 6.0 to evaluate the frequency of recurrent copy number rearrangements, chromosome aneuploidy, and rare copy number variants in patients with adolescent idiopathic scoliosis.

The Scan

WHO Seeks Booster Pause

According to CNN, the World Health Organization is calling for a moratorium on administering SARS-CoV-2 vaccine boosters until more of the world has received initial doses.

For Those Long Legs

With its genome sequence and subsequent RNAi analyses, researchers have examined the genes that give long legs to daddy longlegs, New Scientist says.

September Plans

The New York Times reports that the US Food and Drug Administration is aiming for early September for full approval of the Pfizer-BioNTech SARS-CoV-2 vaccine.

Nucleic Acids Research Papers on Targeting DNA Damage Response, TSMiner, VarSAn

In Nucleic Acids Research this week: genetic changes affecting DNA damage response inhibitor response, "time-series miner" approach, and more.