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In Print: Last Week's Microarray Papers of Note: Jul 15, 2014


Genomic imbalance in products of conception: single-nucleotide polymorphism chromosomal microarray analysis.
Obstet Gynecol. 2014 Jul 7. [Epub ahead of print]
Levy B, et al.

The authors set out to report the full cohort of identifiable anomalies, regardless of known clinical significance, in a large-scale cohort of postmiscarriage products-of-conception samples using a high-resolution SNP microarray platform. They determined that chromosomal microarray analysis of products-of-conception specimens yields a high diagnostic return and that using SNPs extends the scope of detectable genomic abnormalities and facilitates the reporting of true fetal results.

A genome-wide association study of immune response traits in Canadian Holstein cattle.
BMC Genomics. 2014 Jul 4;15(1):559.
Thompson-Crispi K, et al.

The authors performed genome-wide association studies to determine differences in genetic profiles among Holstein cows classified as High or Low for antibody-mediated and cell-mediated immune responses. They genotyped 303 cows using the Illumina Bovine SNP50 BeadChip, and found 186 SNPs, mostly on chromosome 23, that were significantly associated with AMIR, with 21 SNP markers significant for CMIR. They believe it may be feasible to include immune response in genomic breeding indices as an approach to improving animal health.

Are copy number variants associated with adolescent idiopathic scoliosis?
Clin Orthop Relat Res. 2014 Jul 9. [Epub ahead of print]
Buchan J, et al.

The authors used the Affymetrix Genome-wide Human SNP Array 6.0 to evaluate the frequency of recurrent copy number rearrangements, chromosome aneuploidy, and rare copy number variants in patients with adolescent idiopathic scoliosis.

The Scan

Long COVID-19 Susceptibility Clues Contained in Blood Plasma Proteome

A longitudinal study in eBioMedicine found weeks-long blood plasma proteome shifts after SARS-CoV-2 infection, along with proteomic signatures that appeared to coincide with long Covid risk.

Tibetan Study Finds Adaptive Variant Influencing Skin Pigmentation

With a combination of phenotyping and genetic data, researchers document at PNAS a Tibetan-enriched enhancer variant influencing melanin synthesis and ultraviolet light response.

Domestication Linked to Nervous System Genes in Inbred Mouse Strains

Researchers highlighted more than 300 positively selected genes in domesticated mice, including genes linked to nervous system function or behavior in Genome Biology.

ALS Genetic Testing May Be Informative Across Age Ranges, Study Finds

Researchers in the journal Brain identified clinically actionable variants in a significant subset of older ALS patients, prompting them to point to the potential benefits of broader test use.