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In Print: Last Week's Microarray Papers of Note: Jun 17, 2014

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Molecular karyotyping of a dysmorphic girl from Saudi Arabia with CYP1B1-negative primary congenital glaucoma.
Ophthalmic Genet. 2014 Jun 9:1-4. [Epub ahead of print]
Abu-Amero K, et al.

The authors used sequencing and Affymetrix microarrays to study a dysmorphic girl with CYP1B1-negative primary congenital glaucoma from Saudi Arabia, where CYPB1 mutations account for over 90 percent of cases of primary congenital glaucoma and the remaining cases are idiopathic. Array analysis revealed 2 de novo 7p heterozygous duplications and a 4p homozygous microdeletion encompassing one gene only, DTHD1.


A genome-wide association study identifies PLCL2 and AP3D1-DOT1L-SF3A2 as new susceptibility loci for myocardial infarction in Japanese.
Eur J Hum Genet. 2014 Jun 11. [Epub ahead of print]
Hirokawa M, et al.

To identify MI susceptibility loci in Japanese, the authors conducted a GWAS using 1,666 cases and 3,198 controls using the Illumina Human610-QuadBeadChip and HumanHap550v3 Genotyping BeadChip. The study identified two novel susceptibility loci for MI: PLCL2 on chromosome 3p24.3 and AP3D1-DOT1L-SF3A2 on chromosome 19p13.3.


6-Plex microsphere immunoassay with imaging planar array detection for mycotoxins in barley.
Analyst. 2014 Jun 12. [Epub ahead of print]
Peters J, et al.

The authors developed a semi-quantitative 6-plex immunoassay using a suspension array of paramagnetic color-coded microspheres combined with imaging planar array detection for the mycotoxins aflatoxin B1, ochratoxin A, zearalenone, deoxynivalenol, T2-toxin, HT-2 toxin, and fumonisin B1. They report that the resulting low-cost system is transportable, making it attractive for on-site testing in the future.

The Scan

Genetic Risk Factors for Hypertension Can Help Identify Those at Risk for Cardiovascular Disease

Genetically predicted high blood pressure risk is also associated with increased cardiovascular disease risk, a new JAMA Cardiology study says.

Circulating Tumor DNA Linked to Post-Treatment Relapse in Breast Cancer

Post-treatment detection of circulating tumor DNA may identify breast cancer patients who are more likely to relapse, a new JCO Precision Oncology study finds.

Genetics Influence Level of Depression Tied to Trauma Exposure, Study Finds

Researchers examine the interplay of trauma, genetics, and major depressive disorder in JAMA Psychiatry.

UCLA Team Reports Cost-Effective Liquid Biopsy Approach for Cancer Detection

The researchers report in Nature Communications that their liquid biopsy approach has high specificity in detecting all- and early-stage cancers.