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In Print: Last Week's Microarray Papers of Note: Jun 17, 2014


Molecular karyotyping of a dysmorphic girl from Saudi Arabia with CYP1B1-negative primary congenital glaucoma.
Ophthalmic Genet. 2014 Jun 9:1-4. [Epub ahead of print]
Abu-Amero K, et al.

The authors used sequencing and Affymetrix microarrays to study a dysmorphic girl with CYP1B1-negative primary congenital glaucoma from Saudi Arabia, where CYPB1 mutations account for over 90 percent of cases of primary congenital glaucoma and the remaining cases are idiopathic. Array analysis revealed 2 de novo 7p heterozygous duplications and a 4p homozygous microdeletion encompassing one gene only, DTHD1.

A genome-wide association study identifies PLCL2 and AP3D1-DOT1L-SF3A2 as new susceptibility loci for myocardial infarction in Japanese.
Eur J Hum Genet. 2014 Jun 11. [Epub ahead of print]
Hirokawa M, et al.

To identify MI susceptibility loci in Japanese, the authors conducted a GWAS using 1,666 cases and 3,198 controls using the Illumina Human610-QuadBeadChip and HumanHap550v3 Genotyping BeadChip. The study identified two novel susceptibility loci for MI: PLCL2 on chromosome 3p24.3 and AP3D1-DOT1L-SF3A2 on chromosome 19p13.3.

6-Plex microsphere immunoassay with imaging planar array detection for mycotoxins in barley.
Analyst. 2014 Jun 12. [Epub ahead of print]
Peters J, et al.

The authors developed a semi-quantitative 6-plex immunoassay using a suspension array of paramagnetic color-coded microspheres combined with imaging planar array detection for the mycotoxins aflatoxin B1, ochratoxin A, zearalenone, deoxynivalenol, T2-toxin, HT-2 toxin, and fumonisin B1. They report that the resulting low-cost system is transportable, making it attractive for on-site testing in the future.

The Scan

Review of Approval Process

Stat News reports the Department for Health and Human Services' Office of the Inspector General is to investigate FDA's approval of Biogen's Alzheimer's disease drug.

Not Quite Right

A new analysis has found hundreds of studies with incorrect nucleotide sequences reported in their methods, according to Nature News.

CRISPR and mRNA Together

Time magazine reports on the use of mRNA to deliver CRISPR machinery.

Nature Papers Present Smartphone Platform for DNA Diagnosis of Malaria, Mouse Lines for Epigenomic Editing

In Nature this week: a low-cost tool to detect infectious diseases like malaria, and more.