Skip to main content
Premium Trial:

Request an Annual Quote

In Print: Last Week's Microarray Papers of Note: Jun 17, 2014


Molecular karyotyping of a dysmorphic girl from Saudi Arabia with CYP1B1-negative primary congenital glaucoma.
Ophthalmic Genet. 2014 Jun 9:1-4. [Epub ahead of print]
Abu-Amero K, et al.

The authors used sequencing and Affymetrix microarrays to study a dysmorphic girl with CYP1B1-negative primary congenital glaucoma from Saudi Arabia, where CYPB1 mutations account for over 90 percent of cases of primary congenital glaucoma and the remaining cases are idiopathic. Array analysis revealed 2 de novo 7p heterozygous duplications and a 4p homozygous microdeletion encompassing one gene only, DTHD1.

A genome-wide association study identifies PLCL2 and AP3D1-DOT1L-SF3A2 as new susceptibility loci for myocardial infarction in Japanese.
Eur J Hum Genet. 2014 Jun 11. [Epub ahead of print]
Hirokawa M, et al.

To identify MI susceptibility loci in Japanese, the authors conducted a GWAS using 1,666 cases and 3,198 controls using the Illumina Human610-QuadBeadChip and HumanHap550v3 Genotyping BeadChip. The study identified two novel susceptibility loci for MI: PLCL2 on chromosome 3p24.3 and AP3D1-DOT1L-SF3A2 on chromosome 19p13.3.

6-Plex microsphere immunoassay with imaging planar array detection for mycotoxins in barley.
Analyst. 2014 Jun 12. [Epub ahead of print]
Peters J, et al.

The authors developed a semi-quantitative 6-plex immunoassay using a suspension array of paramagnetic color-coded microspheres combined with imaging planar array detection for the mycotoxins aflatoxin B1, ochratoxin A, zearalenone, deoxynivalenol, T2-toxin, HT-2 toxin, and fumonisin B1. They report that the resulting low-cost system is transportable, making it attractive for on-site testing in the future.

The Scan

Positive Framing of Genetic Studies Can Spark Mistrust Among Underrepresented Groups

Researchers in Human Genetics and Genomics Advances report that how researchers describe genomic studies may alienate potential participants.

Small Study of Gene Editing to Treat Sickle Cell Disease

In a Novartis-sponsored study in the New England Journal of Medicine, researchers found that a CRISPR-Cas9-based treatment targeting promoters of genes encoding fetal hemoglobin could reduce disease symptoms.

Gut Microbiome Changes Appear in Infants Before They Develop Eczema, Study Finds

Researchers report in mSystems that infants experienced an enrichment in Clostridium sensu stricto 1 and Finegoldia and a depletion of Bacteroides before developing eczema.

Acute Myeloid Leukemia Treatment Specificity Enhanced With Stem Cell Editing

A study in Nature suggests epitope editing in donor stem cells prior to bone marrow transplants can stave off toxicity when targeting acute myeloid leukemia with immunotherapy.