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In Print: Last Week's Microarray Papers of Note: Jun 3, 2014

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Microarray-based resonance light scattering assay for detecting DNA methylation and human DNA methyltransferase simultaneously with high sensitivity.
Analyst. 2014 Jun 2. [Epub ahead of print]

Ma L, et al.

The authors developed a microarray-based resonance light scattering assay that relies on a combination of methylation-sensitive endonuclease and gold nanoparticle probes to sensitively distinguish DNA methylation levels and to detect human DNA methyltransferase 1.


Recombination locations and rates in beef cattle assessed from parent-offspring pairs.
Genet Sel Evol. 2014 May 29;46(1):34. [Epub ahead of print]
Weng Z, et al.

The authors used the Illumina BovineSNP50 BeadChip to investigate the influence of recombination on haplotype phasing, locate recombination hotspots, scan the genome for quantitative trait loci and identify candidate genes that influence recombination, and quantify the impact of recombination on the accuracy of genotype imputation in beef cattle.


A multiplex high-throughput gene expression assay to simultaneously detect disease and functional markers in induced pluripotent stem cell-derived retinal pigment epithelium.
Stem Cells Transl Med. 2014 May 29. [Epub ahead of print]
Ferrer M, et al.

The authors developed a multiplex high-throughput gene expression assay that simultaneously detects endogenous expression of multiple developmental, functional, and disease markers in iPS cell-derived retinal pigment epithelium and optimized protocols to differentiate iPS cell-derived RPE that was then grown in 96- and 384-well plates.

The Scan

Lung Cancer Response to Checkpoint Inhibitors Reflected in Circulating Tumor DNA

In non-small cell lung cancer patients, researchers find in JCO Precision Oncology that survival benefits after immune checkpoint blockade coincide with a dip in ctDNA levels.

Study Reviews Family, Provider Responses to Rapid Whole-Genome Sequencing Follow-up

Investigators identified in the European Journal of Human Genetics variable follow-up practices after rapid whole-genome sequencing.

BMI-Related Variants Show Age-Related Stability in UK Biobank Participants

Researchers followed body mass index variant stability with genomic structural equation modeling and genome-wide association studies of 40- to 72-year olds in PLOS Genetics.

Genome Sequences Reveal Range Mutations in Induced Pluripotent Stem Cells

Researchers in Nature Genetics detect somatic mutation variation across iPSCs generated from blood or skin fibroblast cell sources, along with selection for BCOR gene mutations.