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In Print: Last Week's Microarray Papers of Note: May 6, 2014


Comparative transcriptome analysis of aerial and subterranean pods development provides insights into seed abortion in peanut.
Plant Mol Biol. 2014 May 5. [Epub ahead of print]
Zhu W, et al.

A comparative transcriptome analysis between aerial and subterranean pods at different developmental stages was produced using a customized NimbleGen microarray representing 36,158 unigenes. By comparing 4 consecutive time-points, a total of 6,203 differentially expressed genes, 4,732 stage-specific expressed genes, and 2,401 specific expressed genes only in aerial or subterranean pods were identified.

New molecular diagnostic kit to assess Y-chromosome deletions in the Japanese population.
Int J Urol. 2014 Apr 29. [Epub ahead of print]
Iijima M, et al.

Deletions in the azoospermia factor regions are the most commonly known molecular genetic cause of human male infertility involving spermatogenetic failure. Testing for these deletions in Japanese DNA samples using conventional sequence-tagged site probes occasionally leads to considerable non-specific or faint products in the Japanese population. The authors developed a Luminex suspension array assay that they claim offers good sensitivity and specificity with time and cost savings.

The Scan

Genome Sequences Reveal Range Mutations in Induced Pluripotent Stem Cells

Researchers in Nature Genetics detect somatic mutation variation across iPSCs generated from blood or skin fibroblast cell sources, along with selection for BCOR gene mutations.

Researchers Reprogram Plant Roots With Synthetic Genetic Circuit Strategy

Root gene expression was altered with the help of genetic circuits built around a series of synthetic transcriptional regulators in the Nicotiana benthamiana plant in a Science paper.

Infectious Disease Tracking Study Compares Genome Sequencing Approaches

Researchers in BMC Genomics see advantages for capture-based Illumina sequencing and amplicon-based sequencing on the Nanopore instrument, depending on the situation or samples available.

LINE-1 Linked to Premature Aging Conditions

Researchers report in Science Translational Medicine that the accumulation of LINE-1 RNA contributes to premature aging conditions and that symptoms can be improved by targeting them.