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In Print: Last Week's Microarray Papers of Note: May 6, 2014


Comparative transcriptome analysis of aerial and subterranean pods development provides insights into seed abortion in peanut.
Plant Mol Biol. 2014 May 5. [Epub ahead of print]
Zhu W, et al.

A comparative transcriptome analysis between aerial and subterranean pods at different developmental stages was produced using a customized NimbleGen microarray representing 36,158 unigenes. By comparing 4 consecutive time-points, a total of 6,203 differentially expressed genes, 4,732 stage-specific expressed genes, and 2,401 specific expressed genes only in aerial or subterranean pods were identified.

New molecular diagnostic kit to assess Y-chromosome deletions in the Japanese population.
Int J Urol. 2014 Apr 29. [Epub ahead of print]
Iijima M, et al.

Deletions in the azoospermia factor regions are the most commonly known molecular genetic cause of human male infertility involving spermatogenetic failure. Testing for these deletions in Japanese DNA samples using conventional sequence-tagged site probes occasionally leads to considerable non-specific or faint products in the Japanese population. The authors developed a Luminex suspension array assay that they claim offers good sensitivity and specificity with time and cost savings.

The Scan

Positive Framing of Genetic Studies Can Spark Mistrust Among Underrepresented Groups

Researchers in Human Genetics and Genomics Advances report that how researchers describe genomic studies may alienate potential participants.

Small Study of Gene Editing to Treat Sickle Cell Disease

In a Novartis-sponsored study in the New England Journal of Medicine, researchers found that a CRISPR-Cas9-based treatment targeting promoters of genes encoding fetal hemoglobin could reduce disease symptoms.

Gut Microbiome Changes Appear in Infants Before They Develop Eczema, Study Finds

Researchers report in mSystems that infants experienced an enrichment in Clostridium sensu stricto 1 and Finegoldia and a depletion of Bacteroides before developing eczema.

Acute Myeloid Leukemia Treatment Specificity Enhanced With Stem Cell Editing

A study in Nature suggests epitope editing in donor stem cells prior to bone marrow transplants can stave off toxicity when targeting acute myeloid leukemia with immunotherapy.