Skip to main content
Premium Trial:

Request an Annual Quote

In Print: Last Week's Microarray Papers of Note: Apr 15, 2014


Transcriptional landscape of the prenatal human brain.
Nature. 2014 Apr 10;508(7495):199-206.
Miller J, et al.

The authors describe an anatomically comprehensive atlas of the mid-gestational human brain, including de novo reference atlases, in situ hybridization, ultra-high-resolution magnetic resonance imaging, and microarray analysis on highly discrete laser-microdissected brain regions.

Prenatal diagnosis of congenital heart defect by genome-wide high resolution SNP array.
Prenat Diagn. 2014 Apr 9. [Epub ahead of print]
Can L, et al.

The authors set out detect genomic imbalances in fetuses with congenital heart defect using the Affymetrix CytoScan HD array. Clinically significant copy number variations were detected in one fifth of fetuses surveyed. The authors claim the results "demonstrate the value of high resolution SNP arrays in prenatal diagnosis of CHD," and believe the approach "should become an integral aspect in clinically molecular diagnosis and genetic counseling."

Mapping in an apple (Malus x domestica) F1 segregating population based on physical clustering of differentially expressed genes.
BMC Genomics. 2014 Apr 4;15(1):261.
Jensen P, et al.

The authors aimed to identify genes whose steady-state transcript abundance was associated with inheritance of specific traits segregating in an apple breeding population, including resistance to powdery mildew disease and woolly apple aphid. Using a custom array representing 26,000 transcripts, they identified small sets of genes with trait-associated expression levels.

The Scan

Positive Framing of Genetic Studies Can Spark Mistrust Among Underrepresented Groups

Researchers in Human Genetics and Genomics Advances report that how researchers describe genomic studies may alienate potential participants.

Small Study of Gene Editing to Treat Sickle Cell Disease

In a Novartis-sponsored study in the New England Journal of Medicine, researchers found that a CRISPR-Cas9-based treatment targeting promoters of genes encoding fetal hemoglobin could reduce disease symptoms.

Gut Microbiome Changes Appear in Infants Before They Develop Eczema, Study Finds

Researchers report in mSystems that infants experienced an enrichment in Clostridium sensu stricto 1 and Finegoldia and a depletion of Bacteroides before developing eczema.

Acute Myeloid Leukemia Treatment Specificity Enhanced With Stem Cell Editing

A study in Nature suggests epitope editing in donor stem cells prior to bone marrow transplants can stave off toxicity when targeting acute myeloid leukemia with immunotherapy.