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In Print: Last Week's Microarray Papers of Note: Apr 15, 2014


Transcriptional landscape of the prenatal human brain.
Nature. 2014 Apr 10;508(7495):199-206.
Miller J, et al.

The authors describe an anatomically comprehensive atlas of the mid-gestational human brain, including de novo reference atlases, in situ hybridization, ultra-high-resolution magnetic resonance imaging, and microarray analysis on highly discrete laser-microdissected brain regions.

Prenatal diagnosis of congenital heart defect by genome-wide high resolution SNP array.
Prenat Diagn. 2014 Apr 9. [Epub ahead of print]
Can L, et al.

The authors set out detect genomic imbalances in fetuses with congenital heart defect using the Affymetrix CytoScan HD array. Clinically significant copy number variations were detected in one fifth of fetuses surveyed. The authors claim the results "demonstrate the value of high resolution SNP arrays in prenatal diagnosis of CHD," and believe the approach "should become an integral aspect in clinically molecular diagnosis and genetic counseling."

Mapping in an apple (Malus x domestica) F1 segregating population based on physical clustering of differentially expressed genes.
BMC Genomics. 2014 Apr 4;15(1):261.
Jensen P, et al.

The authors aimed to identify genes whose steady-state transcript abundance was associated with inheritance of specific traits segregating in an apple breeding population, including resistance to powdery mildew disease and woolly apple aphid. Using a custom array representing 26,000 transcripts, they identified small sets of genes with trait-associated expression levels.