Skip to main content
Premium Trial:

Request an Annual Quote

In Print: Last Week's Microarray Papers of Note: Apr 1, 2014


An economic analysis of prenatal cytogenetic technologies for sonographically detected fetal anomalies.
Am J Med Genet A. 2014 Mar 24. [Epub ahead of print]
Harper L, et al.

In this study, the authors performed an economic analysis of cytogenetic technologies in the prenatal diagnosis of sonographically detected fetal anomalies comparing four strategies: (karyotype alone, CMA alone, karyotype and CMA, and karyotype followed by CMA if the karyotype was normal. They determined that CMA alone was the most cost-effective strategy, although karyotype alone and CMA following a normal karyotype are both acceptable alternatives.

Genome-wide DNA methylation analysis of formalin-fixed paraffin embedded colorectal cancer tissue.
Genes Chromosomes Cancer. 2014 Mar 28. [Epub ahead of print]
Dumenil T, et al.

The authors compared fresh and matched FFPE tissue DNA samples using the Illumina Infinium HD Human Methylation 450K BeadChip platform with a companion application for repair and restoration of DNA from FFPE tissue. Their results showed good correlation between fresh and FFPE sample data.

Reference intervals for urinary renal injury biomarkers KIM-1 and NGAL in healthy children.
Biomark Med. 2014 Mar 24. [Epub ahead of print]
McWilliam S, et al.

The aim of this study was to establish reference intervals in healthy children for two novel urinary biomarkers of acute kidney injury, kidney injury molecule-1 (KIM-1) and neutrophil gelatinase-associated lipocalin (NGAL) using both Meso Scale Discovery and Luminex-based analytical approaches. They identified consistently higher NGAL concentrations in females than males and lower KIM-1 concentrations in African-Americans than Caucasians.

The Scan

Positive Framing of Genetic Studies Can Spark Mistrust Among Underrepresented Groups

Researchers in Human Genetics and Genomics Advances report that how researchers describe genomic studies may alienate potential participants.

Small Study of Gene Editing to Treat Sickle Cell Disease

In a Novartis-sponsored study in the New England Journal of Medicine, researchers found that a CRISPR-Cas9-based treatment targeting promoters of genes encoding fetal hemoglobin could reduce disease symptoms.

Gut Microbiome Changes Appear in Infants Before They Develop Eczema, Study Finds

Researchers report in mSystems that infants experienced an enrichment in Clostridium sensu stricto 1 and Finegoldia and a depletion of Bacteroides before developing eczema.

Acute Myeloid Leukemia Treatment Specificity Enhanced With Stem Cell Editing

A study in Nature suggests epitope editing in donor stem cells prior to bone marrow transplants can stave off toxicity when targeting acute myeloid leukemia with immunotherapy.