An economic analysis of prenatal cytogenetic technologies for sonographically detected fetal anomalies.
Am J Med Genet A. 2014 Mar 24. [Epub ahead of print]
Harper L, et al.
In this study, the authors performed an economic analysis of cytogenetic technologies in the prenatal diagnosis of sonographically detected fetal anomalies comparing four strategies: (karyotype alone, CMA alone, karyotype and CMA, and karyotype followed by CMA if the karyotype was normal. They determined that CMA alone was the most cost-effective strategy, although karyotype alone and CMA following a normal karyotype are both acceptable alternatives.
Genome-wide DNA methylation analysis of formalin-fixed paraffin embedded colorectal cancer tissue.
Genes Chromosomes Cancer. 2014 Mar 28. [Epub ahead of print]
Dumenil T, et al.
The authors compared fresh and matched FFPE tissue DNA samples using the Illumina Infinium HD Human Methylation 450K BeadChip platform with a companion application for repair and restoration of DNA from FFPE tissue. Their results showed good correlation between fresh and FFPE sample data.
Reference intervals for urinary renal injury biomarkers KIM-1 and NGAL in healthy children.
Biomark Med. 2014 Mar 24. [Epub ahead of print]
McWilliam S, et al.
The aim of this study was to establish reference intervals in healthy children for two novel urinary biomarkers of acute kidney injury, kidney injury molecule-1 (KIM-1) and neutrophil gelatinase-associated lipocalin (NGAL) using both Meso Scale Discovery and Luminex-based analytical approaches. They identified consistently higher NGAL concentrations in females than males and lower KIM-1 concentrations in African-Americans than Caucasians.