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In Print: Last Week's Microarray Papers of Note: Apr 1, 2014


An economic analysis of prenatal cytogenetic technologies for sonographically detected fetal anomalies.
Am J Med Genet A. 2014 Mar 24. [Epub ahead of print]
Harper L, et al.

In this study, the authors performed an economic analysis of cytogenetic technologies in the prenatal diagnosis of sonographically detected fetal anomalies comparing four strategies: (karyotype alone, CMA alone, karyotype and CMA, and karyotype followed by CMA if the karyotype was normal. They determined that CMA alone was the most cost-effective strategy, although karyotype alone and CMA following a normal karyotype are both acceptable alternatives.

Genome-wide DNA methylation analysis of formalin-fixed paraffin embedded colorectal cancer tissue.
Genes Chromosomes Cancer. 2014 Mar 28. [Epub ahead of print]
Dumenil T, et al.

The authors compared fresh and matched FFPE tissue DNA samples using the Illumina Infinium HD Human Methylation 450K BeadChip platform with a companion application for repair and restoration of DNA from FFPE tissue. Their results showed good correlation between fresh and FFPE sample data.

Reference intervals for urinary renal injury biomarkers KIM-1 and NGAL in healthy children.
Biomark Med. 2014 Mar 24. [Epub ahead of print]
McWilliam S, et al.

The aim of this study was to establish reference intervals in healthy children for two novel urinary biomarkers of acute kidney injury, kidney injury molecule-1 (KIM-1) and neutrophil gelatinase-associated lipocalin (NGAL) using both Meso Scale Discovery and Luminex-based analytical approaches. They identified consistently higher NGAL concentrations in females than males and lower KIM-1 concentrations in African-Americans than Caucasians.

The Scan

Purnell Choppin Dies

Purnell Choppin, a virologist who led the Howard Hughes Medical Institute, has died at 91, according to the Washington Post.

Effectiveness May Decline, Data From Israel Suggests

The New York Times reports that new Israeli data suggests a decline in Pfizer-BioNTech SARS-CoV-2 vaccine effectiveness against Delta variant infection, though protection against severe disease remains high.

To See Future Risk

Slate looks into the use of polygenic risk scores in embryo screening.

PLOS Papers on Methicillin-Resistant Staphylococcus, Bone Marrow Smear Sequencing, More

In PLOS this week: genomic analysis of methicillin-resistant Staphylococcus pseudintermedius, archived bone marrow sequencing, and more.