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In Print: Last Week's Microarray Papers of Note: Mar 25, 2014

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Signature of backward replication slippage at the copy number variation junction.
J Hum Genet. 2014 Mar 20. [Epub ahead of print]
Ohye T, et al.

The authors used chromsomal microarrays to analyze the del(2)(q13q14.2) chromosomal junction site observed in a woman with a recurrent pregnancy loss. They were able to demarcate a 2.8 megabase deletion that does not appear in the database of human genomic variations.


Simultaneous detection of IgG antibodies associated with viral hemorrhagic fever by a multiplexed Luminex-based immunoassay.
Virus Res. 2014 Mar 12. [Epub ahead of print]
Wu W, et al.

The authors developed a multi-pathogen and high-throughput method that can simultaneously detect hemorrhagic fever virus-specific IgG antibodies using Luminex xMAP technology. Recombinant antigens of nine HFVs including Hantaan virus, Seoul virus, Puumala virus, Andes virus, Sin Nombre virus, Crimean-Congo hemorrhagic fever virus, Rift Valley fever virus, severe fever with thrombocytopenia syndrome bunyavirus, and dengue virus were produced and purified from a prokaryotic expression system and the influence of the coupling amount was investigated.


Transcriptome sequencing and profiling of expressed genes in cambial zone and differentiating xylem of Japanese cedar (Cryptomeria japonica).
BMC Genomics. 2014 Mar 20;15(1):219. [Epub ahead of print]

Mishima K, et al.

After identifying expressed sequence tags in Japanese cedar tissue undergoing xylogenesis, the authors designed a custom cDNA microarray to compare expression of highly regulated genes throughout a growing season. This led to identification of candidate genes involved both in wood formation and later cessation of growth and dormancy.

The Scan

Genome Sequences Reveal Range Mutations in Induced Pluripotent Stem Cells

Researchers in Nature Genetics detect somatic mutation variation across iPSCs generated from blood or skin fibroblast cell sources, along with selection for BCOR gene mutations.

Researchers Reprogram Plant Roots With Synthetic Genetic Circuit Strategy

Root gene expression was altered with the help of genetic circuits built around a series of synthetic transcriptional regulators in the Nicotiana benthamiana plant in a Science paper.

Infectious Disease Tracking Study Compares Genome Sequencing Approaches

Researchers in BMC Genomics see advantages for capture-based Illumina sequencing and amplicon-based sequencing on the Nanopore instrument, depending on the situation or samples available.

LINE-1 Linked to Premature Aging Conditions

Researchers report in Science Translational Medicine that the accumulation of LINE-1 RNA contributes to premature aging conditions and that symptoms can be improved by targeting them.