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In Print: Last Week's Microarray Papers of Note: Mar 18, 2014


A revised design for microarray experiments to account for experimental noise and uncertainty of probe response.
PLoS One. 2014 Mar 11;9(3):e91295.
Pozhitkov A, et al.

The researchers developed a new experimental design that produces calibrated microarrays capable of directly measuring gene expression as well as gene copy number, without a need for follow up verification. BioArray News spoke recently with co-author Peter Noble about the new approach (see related story, this issue).

The impact of chromosomal microarray on clinical management: a retrospective analysis.
Genet Med. 2014 Mar 13. [Epub ahead of print]
Henderson L, et al.

The authors retrospectively reviewed the electronic medical records of all patients who had abnormal chromosomal microarray findings over a 3-year period and quantified the management recommendations made in response to these results. They reported that in the majority of cases, abnormal CMA findings led to health management decisions, including pharmacological treatment, cancer-related screening or exclusion of screening, contraindications, and referrals for further evaluation.

Simultaneous detection of RNA and DNA targets based on multiplex isothermal amplification.
J Agric Food Chem. 2014 Mar 13. [Epub ahead of print]
Dobnik D, et al.

The authors developed an isothermal nucleic-acid-sequence-based amplification (NASBA)-implemented microarray analysis procedure that is suitable for the simultaneous multiplex amplification of RNA and DNA targets. In the paper they demonstrated its use for the detection of two potato pathogens, the potato spindle tuber viroid, which has an RNA target, and Ralstonia solanacearum, which has a DNA target.

Single molecule characterization of DNA binding and strand displacement reactions on lithographic DNA origami microarrays.
Nano Lett. 2014 Mar 12;14(3):1627-33.
Scheible M, et al.

Based on a so-called origami hybrid assembly protocol using DNA self-assembly and electron-beam lithography on transparent glass substrates, the authors developed a DNA origami microarray that is compatible with the requirements of single molecule fluorescence and super-resolution microscopy.

The Scan

Positive Framing of Genetic Studies Can Spark Mistrust Among Underrepresented Groups

Researchers in Human Genetics and Genomics Advances report that how researchers describe genomic studies may alienate potential participants.

Small Study of Gene Editing to Treat Sickle Cell Disease

In a Novartis-sponsored study in the New England Journal of Medicine, researchers found that a CRISPR-Cas9-based treatment targeting promoters of genes encoding fetal hemoglobin could reduce disease symptoms.

Gut Microbiome Changes Appear in Infants Before They Develop Eczema, Study Finds

Researchers report in mSystems that infants experienced an enrichment in Clostridium sensu stricto 1 and Finegoldia and a depletion of Bacteroides before developing eczema.

Acute Myeloid Leukemia Treatment Specificity Enhanced With Stem Cell Editing

A study in Nature suggests epitope editing in donor stem cells prior to bone marrow transplants can stave off toxicity when targeting acute myeloid leukemia with immunotherapy.