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In Print: Last Week's Microarray Papers of Note: Mar 11, 2014


Development of a novel, quantitative protein microarray platform for the multiplexed serological analysis of autoantibodies to cancer-testis antigens.
Int J Cancer. 2014 Mar 6. [Epub ahead of print]
Beeton-Kempen N,et al.

The authors describe the development of a customizable cancer-testis antigen microarray platform and bioinformatics tools for quantifying anti-cancer testis antigen autoantibody profiles in patient sera. They demonstrate the use of the platform in monitoring the response of a melanoma patient cohort to an experimental therapeutic NY-ESO-1-based cancer vaccine.

Direct covalent attachment of DNA microarrays by rapid thiol-ene "click" chemistry.
Bioconjug Chem. 2014 Mar 4. [Epub ahead of print]
Escorihuela J, et al.

The authors present a strategy for covalently immobilizing DNA onto silicon-based materials using UV-initiated thiol-ene reactions. The authors claim the approach has the advantages of spatially controlled probe anchoring, direct attachment without using cross-linkers, and short irradiation times.

Genomic profiling reveals extensive heterogeneity in somatic DNA copy number aberrations of canine hemangiosarcoma.
Chromosome Res. 2014 Mar 6. [Epub ahead of print]
Thomas R, et al.

The authors performed genome-wide, microarray-based somatic DNA copy number profiling of 75 primary intra-abdominal hemangiosarcomas from five popular dog breeds that are highly predisposed to canine hemangiosarcoma. Copy number alterations involving CDKN2A, VEGFA, and the SKI oncogene were identified as potential driver aberrations of hemangiosarcoma development, highlighting potential targets for therapeutic modulation.

The Scan

Positive Framing of Genetic Studies Can Spark Mistrust Among Underrepresented Groups

Researchers in Human Genetics and Genomics Advances report that how researchers describe genomic studies may alienate potential participants.

Small Study of Gene Editing to Treat Sickle Cell Disease

In a Novartis-sponsored study in the New England Journal of Medicine, researchers found that a CRISPR-Cas9-based treatment targeting promoters of genes encoding fetal hemoglobin could reduce disease symptoms.

Gut Microbiome Changes Appear in Infants Before They Develop Eczema, Study Finds

Researchers report in mSystems that infants experienced an enrichment in Clostridium sensu stricto 1 and Finegoldia and a depletion of Bacteroides before developing eczema.

Acute Myeloid Leukemia Treatment Specificity Enhanced With Stem Cell Editing

A study in Nature suggests epitope editing in donor stem cells prior to bone marrow transplants can stave off toxicity when targeting acute myeloid leukemia with immunotherapy.