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In Print: Last Week's Microarray Papers of Note: Feb 18, 2014

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DNA methylation profiling can classify HIV-associated lymphomas.
AIDS. 2014 Feb 20;28(4):503-10.
Matsunaga A, et al.

To investigate the features of HIV-associated lymphomas, the authors performed genome-wide DNA methylation profiling of HIV and non-HIV lymphomas using Illumina GoldenGate Methylation Cancer Panel I and Illumina Infinium HumanMethylation450 BeadChip microarrays. The analyses of promoter regions revealed unique DNA methylation profiles in HIV-associated lymphomas, suggesting profile differences compared with non-HIV lymphomas.


A genome-wide association study of production traits in a commercial population of Large White pigs: evidence of haplotypes affecting meat quality.
Genet Sel Evol. 2014 Feb 14;46(1):12. [Epub ahead of print]
Sanchez M, et al.

Analysis with the PorcineSNP60 BeadChip enabled the detection of 23 quantitative trait loci regions that affect feed consumption, carcass, and meat quality traits in a Large White pig population, of which 13 were novel QTL. The proportionally larger number of QTL found for meat quality traits suggests a specific opportunity for improving these traits in the pig by genomic selection, according to the authors.


Developing standards for chromosomal microarray testing counselling in pediatrics.
Acta Paediatr. 2014 Feb 17. [Epub ahead of print]
Godfrey E, et al.

The authors developed standards for counseling and giving families results following chromosomal microarray analysis. They evaluated these standards in cases seen by the Auckland Developmental Pediatric team in New Zealand in 2011.

The Scan

Self-Reported Hearing Loss in Older Adults Begins Very Early in Life, Study Says

A JAMA Otolaryngology — Head & Neck Surgery study says polygenic risk scores associated with hearing loss in older adults is also associated with hearing decline in younger groups.

Genome-Wide Analysis Sheds Light on Genetics of ADHD

A genome-wide association study meta-analysis of attention-deficit hyperactivity disorder appearing in Nature Genetics links 76 genes to risk of having the disorder.

MicroRNA Cotargeting Linked to Lupus

A mouse-based study appearing in BMC Biology implicates two microRNAs with overlapping target sites in lupus.

Enzyme Involved in Lipid Metabolism Linked to Mutational Signatures

In Nature Genetics, a Wellcome Sanger Institute-led team found that APOBEC1 may contribute to the development of the SBS2 and SBS13 mutational signatures in the small intestine.