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In Print: Last Week's Microarray Papers of Note: Jan 21, 2014


Genome-wide copy number variation study and gene expression analysis identify ABI3BP as a susceptibility gene for Kashin-Beck disease.
Hum Genet. 2014 Jan 21. [Epub ahead of print]
Zhang F, et al.

The authors conducted the first genome-wide copy number variation study of KBD involving 2,743 Chinese Han adults. The study was first performed using Affymetrix Human SNP 6.0 Arrays. The identified copy number variations were then replicated in an independent Chinese Han sample containing 1,026 subjects.

Evaluation of homo- and hetero-functionally activated glass surfaces for optimized antibody arrays.
Anal Biochem. 2014 Jan 15. pii: S0003-2697(14)00014-1. [Epub ahead of print]
González-González M, et al.

The authors describe novel hetero-functionally activated glass surfaces favoring oriented antibody binding for improved performance in protein microarray applications. In a trial study, the technology enabled the concurrent detection of a set of membrane proteins under native conditions in a specific, selective, and semi-quantitative manner and in a single assay.

Echinacea purpurea (L.) Moench modulates human T-cell cytokine response.
Int Immunopharmacol. 2014 Jan 13. pii: S1567-5769(13)00508-0.
Fonseca F, et al.

The authors used Luminex bead-based immunoassays and flow cytometry to evaluate the composition of a neutral and weakly acidic water-soluble extract from Echinacea purpurea (L.) Moench, previously shown to modify the course of influenza infection in a mouse model, and to assess potential immunomodulatory effects on human T cells.

The Scan

Genetic Tests Lead to Potential Prognostic Variants in Dutch Children With Dilated Cardiomyopathy

Researchers in Circulation: Genomic and Precision Medicine found that the presence of pathogenic or likely pathogenic variants was linked to increased risk of death and poorer outcomes in children with pediatric dilated cardiomyopathy.

Fragile X Syndrome Mutations Found With Comprehensive Testing Method

Researchers in Clinical Chemistry found fragile X syndrome expansions and other FMR1 mutations with ties to the intellectual disability condition using a long-range PCR and long-read sequencing approach.

Team Presents Strategy for Speedy Species Detection in Metagenomic Sequence Data

A computational approach presented in PLOS Computational Biology produced fewer false-positive species identifications in simulated and authentic metagenomic sequences.

Genetic Risk Factors for Hypertension Can Help Identify Those at Risk for Cardiovascular Disease

Genetically predicted high blood pressure risk is also associated with increased cardiovascular disease risk, a new JAMA Cardiology study says.