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In Print: Last Week's Microarray Papers of Note: Jan 21, 2014


Genome-wide copy number variation study and gene expression analysis identify ABI3BP as a susceptibility gene for Kashin-Beck disease.
Hum Genet. 2014 Jan 21. [Epub ahead of print]
Zhang F, et al.

The authors conducted the first genome-wide copy number variation study of KBD involving 2,743 Chinese Han adults. The study was first performed using Affymetrix Human SNP 6.0 Arrays. The identified copy number variations were then replicated in an independent Chinese Han sample containing 1,026 subjects.

Evaluation of homo- and hetero-functionally activated glass surfaces for optimized antibody arrays.
Anal Biochem. 2014 Jan 15. pii: S0003-2697(14)00014-1. [Epub ahead of print]
González-González M, et al.

The authors describe novel hetero-functionally activated glass surfaces favoring oriented antibody binding for improved performance in protein microarray applications. In a trial study, the technology enabled the concurrent detection of a set of membrane proteins under native conditions in a specific, selective, and semi-quantitative manner and in a single assay.

Echinacea purpurea (L.) Moench modulates human T-cell cytokine response.
Int Immunopharmacol. 2014 Jan 13. pii: S1567-5769(13)00508-0.
Fonseca F, et al.

The authors used Luminex bead-based immunoassays and flow cytometry to evaluate the composition of a neutral and weakly acidic water-soluble extract from Echinacea purpurea (L.) Moench, previously shown to modify the course of influenza infection in a mouse model, and to assess potential immunomodulatory effects on human T cells.

The Scan

Positive Framing of Genetic Studies Can Spark Mistrust Among Underrepresented Groups

Researchers in Human Genetics and Genomics Advances report that how researchers describe genomic studies may alienate potential participants.

Small Study of Gene Editing to Treat Sickle Cell Disease

In a Novartis-sponsored study in the New England Journal of Medicine, researchers found that a CRISPR-Cas9-based treatment targeting promoters of genes encoding fetal hemoglobin could reduce disease symptoms.

Gut Microbiome Changes Appear in Infants Before They Develop Eczema, Study Finds

Researchers report in mSystems that infants experienced an enrichment in Clostridium sensu stricto 1 and Finegoldia and a depletion of Bacteroides before developing eczema.

Acute Myeloid Leukemia Treatment Specificity Enhanced With Stem Cell Editing

A study in Nature suggests epitope editing in donor stem cells prior to bone marrow transplants can stave off toxicity when targeting acute myeloid leukemia with immunotherapy.