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In Print: Last Week's Microarray Papers of Note: Jan 7, 2014


Variable approaches to genetic counseling for microarray regions of homozygosity associated with parental relatedness.
Am J Med Genet A. 2014 Jan;164(1):87-98.
Grote L, et al.

A 35 question survey was administered to 240 genetic counselors and geneticists who had ordered or counseled for SNP microarray analysis. Based on this survey, the authors were able to describe pre- and post-test counseling practices of genetics professionals regarding regions of homozygosity, explore perceived comfort and ethical concerns in the follow-up of such results, demonstrate awareness of laws surrounding duty to report consanguinity and incest, and allow respondents to share their personal experiences with results suggesting a parental relationship.

Profiling of the yak skeletal muscle tissue gene expression and comparison with the domestic cattle by genome array.
Animal. 2014 Jan;8(1):28-35.
Wang H, et al.

The authors used bovine genome arrays to investigate the molecular mechanism involved in meat quality differences between the two Chinese special varieties: Qinghai yak and Qinchuan cattle. A dozen chemical-physical characteristics of the longissimus dorsi muscle related to meat quality were compared at the age of 36 months, and the gene expression profiles were constructed. Quantitative real-time PCR was also performed to validate some differentially expressed genes identified by microarray.

44-plex cytokine profile of cholesteatoma.
Acta Otolaryngol. 2014 Jan;134(1):41-50.
Britze A, et al.

The authors developed a Luminex multiplex xMAP-based antibody assay for the simultaneous analysis of 44 cytokines in cholesteatoma. They found high levels of interleukin 21 expressed in cholesteatoma that could explain its expansive growth and could serve as future drug target.

Confined placental mosaicism: implications for fetal chromosomal analysis using microarray comparative genomic hybridization.
Prenat Diagn. 2014 Jan;34(1):98-101.
Karampetsou E, et al.

According to the authors, confined placental mosaicism can occur for submicroscopic copy number changes detected by array comparative genomic hybridization in DNA from uncultured chorionic villi samples. In order to minimize the risk of false-positive results in these cases, they wrote that detected copy number changes should be confirmed in a different source of material, such as cultured cells.