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In Print: Last Week's Microarray Papers of Note: Dec 17, 2013


TE-array – a high throughput tool to study transposon transcription.

BMC Genomics. 2013 Dec 10;14(1):869. [Epub ahead of print]

Gnanakkan V, et al.

To characterize the contribution of transposons to mammalian transcriptomes, the authors developed a custom microarray platform with probes covering known human and mouse transposons in both sense and antisense orientations. They called this platform the TE-array, profiled TE repeat expression in a panel of normal mouse tissues, and validated their findings using the NanoString nCounter platform and RNAseq.

Epimutation profiling in Beckwith-Wiedemann syndrome: relationship with assisted reproductive technology.

Clin Epigenetics. 2013 Dec 10;5(1):23. [Epub ahead of print]

Tee L, et al.

The authors investigated the relationship between multiple loss of methylation, or epimutation, cases, a history of using assisted reproductive technologies, and clinical phenotype in a cohort of 187 Beckwith-Wiedemann patients using Illumina methylation arrays.

De novo copy number variations in cloned dogs from the same nuclear donor.

BMC Genomics. 2013 Dec 9;14(1):863. [Epub ahead of print]

Jung S, et al.

The authors analyzed CNVs in seven cloned dogs using the nuclear donor genome as reference by array CGH, and identified five de novo CNVs in two of the seven clones. They claim their paper is the first report of de novo CNVs in the cloned dogs which were generated by somatic cell nuclear transfer technology.

The Scan

Genetic Risk Factors for Hypertension Can Help Identify Those at Risk for Cardiovascular Disease

Genetically predicted high blood pressure risk is also associated with increased cardiovascular disease risk, a new JAMA Cardiology study says.

Circulating Tumor DNA Linked to Post-Treatment Relapse in Breast Cancer

Post-treatment detection of circulating tumor DNA may identify breast cancer patients who are more likely to relapse, a new JCO Precision Oncology study finds.

Genetics Influence Level of Depression Tied to Trauma Exposure, Study Finds

Researchers examine the interplay of trauma, genetics, and major depressive disorder in JAMA Psychiatry.

UCLA Team Reports Cost-Effective Liquid Biopsy Approach for Cancer Detection

The researchers report in Nature Communications that their liquid biopsy approach has high specificity in detecting all- and early-stage cancers.