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In Print: Last Week's Microarray Papers of Note: Dec 17, 2013


TE-array – a high throughput tool to study transposon transcription.

BMC Genomics. 2013 Dec 10;14(1):869. [Epub ahead of print]

Gnanakkan V, et al.

To characterize the contribution of transposons to mammalian transcriptomes, the authors developed a custom microarray platform with probes covering known human and mouse transposons in both sense and antisense orientations. They called this platform the TE-array, profiled TE repeat expression in a panel of normal mouse tissues, and validated their findings using the NanoString nCounter platform and RNAseq.

Epimutation profiling in Beckwith-Wiedemann syndrome: relationship with assisted reproductive technology.

Clin Epigenetics. 2013 Dec 10;5(1):23. [Epub ahead of print]

Tee L, et al.

The authors investigated the relationship between multiple loss of methylation, or epimutation, cases, a history of using assisted reproductive technologies, and clinical phenotype in a cohort of 187 Beckwith-Wiedemann patients using Illumina methylation arrays.

De novo copy number variations in cloned dogs from the same nuclear donor.

BMC Genomics. 2013 Dec 9;14(1):863. [Epub ahead of print]

Jung S, et al.

The authors analyzed CNVs in seven cloned dogs using the nuclear donor genome as reference by array CGH, and identified five de novo CNVs in two of the seven clones. They claim their paper is the first report of de novo CNVs in the cloned dogs which were generated by somatic cell nuclear transfer technology.