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In Print: Last Week's Microarray Papers of Note: Dec 10, 2013


A new bead-based human platelet antigen antibodies detection assay versus the monoclonal antibody immobilization of platelet antigens assay.
Transfusion. 2013 Dec 3. doi: 10.1111/trf.12509. [Epub ahead of print]
Porcelijn L, et al.

The authors compared the performance of a newly developed Luminex bead-based platelet antibody detection method with the monoclonal antibody immobilization of PLT antigens assay and the LifeScreen Deluxe Luminex bead-based HLA Class I antibody detection method.

Changing interpretation of chromosomal microarray over time in a community cohort with intellectual disability.
Am J Med Genet A. 2013 Dec 5. [Epub ahead of print]
Palmer E, et al.

In 2010, the authors used high-resolution arrays to analyze a community cohort of 67 individuals with intellectual disability of unknown etiology. Three hundred and one CNVs were detected and analyzed using contemporary resources and a simple scoring system. But when they re-analyzed the CNV data in 2012 using newer interpretative resources, there was a statistically significant difference in the assessment of individual CNVs. An additional eight patients were reassessed as having a potentially pathogenic array, they found, and several additional susceptibility or modifier CNVs were identified.

Reproducibility and reliability of SNP analysis using human cellular DNA at or near nanogram levels.
BMC Res Notes. 2013 Dec 6;6(1):515. [Epub ahead of print]
Okitsu C, et al.

The authors aimed to determine the reproducibility and reliability of Illumina SNPs array assays when DNA sample amounts less than the recommended 200 nanograms are used. They found that reasonably reproducible and reliable results can be obtained with quantities of DNA, as low as 0.8 ng, equivalent to 133 human cells, well below the manufacturer's recommendation.

The Scan

Pig Organ Transplants Considered

The Wall Street Journal reports that the US Food and Drug Administration may soon allow clinical trials that involve transplanting pig organs into humans.

'Poo-Bank' Proposal

Harvard Medical School researchers suggest people should bank stool samples when they are young to transplant when they later develop age-related diseases.

Spurred to Develop Again

New Scientist reports that researchers may have uncovered why about 60 percent of in vitro fertilization embryos stop developing.

Science Papers Examine Breast Milk Cell Populations, Cerebral Cortex Cellular Diversity, Micronesia Population History

In Science this week: unique cell populations found within breast milk, 100 transcriptionally distinct cell populations uncovered in the cerebral cortex, and more.