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In Print: Last Week's Microarray Papers of Note: Nov 19, 2013

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Characterization of fetal cells from the maternal circulation by microarray gene expression analysis – could the extravillous trophoblasts be a target for future cell-based non-invasive prenatal diagnosis?
Fetal Diagn Ther. 2013 Nov 9. [Epub ahead of print]
Hatt L, et al.

In this study, fetal cells were enriched from maternal blood by magnetic-activated cell sorting using the endothelial cell marker CD105 and identified by XY fluorescence in situ hybridization. Expression patterns were compared between fetal cells and maternal blood cells using stem cell microarray analysis. More than half of these are genes identified are known to be expressed in the placenta, especially in extravillous trophoblasts, or EVTs. The authors hypothesize that EVTs could be the basis for future cell-based non-invasive prenatal diagnosis.


Transcriptome sequencing and microarray design for functional genomics in the extremophile Arabidopsis relativeThellungiella salsuginea (Eutrema salsugineum).
BMC Genomics. 2013 Nov 14;14(1):793. [Epub ahead of print]
Lee Y, et al.

Thellungiella salsuginea has attracted interest as an alternative plant model species with high tolerance of various abiotic stresses, according to the authors. In this paper, they report the results of de novo transcriptome assembly and annotation based on pyrosequencing and development and validation of a T. salsuginea microarray. The developed microarrays were used to investigate transcriptional responses of T. Salsuginea and Arabidopsis during cold acclimation.


Microsphere-based immunoassay for the detection of azaspiracids.
Anal Biochem. 2013 Nov 8. [Epub ahead of print]
Rodríguez L, et al.

Azaspiracids, or AZAs, are a group of lipophilic toxins found in shellfish. The authors of this study developed a microsphere-based immunoassay for the detection of AZAs on the Luminex system. The method is based on the competition between AZA-2 immobilized onto the surface of microspheres and free AZAs for interaction with a monoclonal anti-azaspiracid antibody.

The Scan

Self-Reported Hearing Loss in Older Adults Begins Very Early in Life, Study Says

A JAMA Otolaryngology — Head & Neck Surgery study says polygenic risk scores associated with hearing loss in older adults is also associated with hearing decline in younger groups.

Genome-Wide Analysis Sheds Light on Genetics of ADHD

A genome-wide association study meta-analysis of attention-deficit hyperactivity disorder appearing in Nature Genetics links 76 genes to risk of having the disorder.

MicroRNA Cotargeting Linked to Lupus

A mouse-based study appearing in BMC Biology implicates two microRNAs with overlapping target sites in lupus.

Enzyme Involved in Lipid Metabolism Linked to Mutational Signatures

In Nature Genetics, a Wellcome Sanger Institute-led team found that APOBEC1 may contribute to the development of the SBS2 and SBS13 mutational signatures in the small intestine.