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In Print: Last Week's Microarray Papers of Note: Nov 12, 2013


Identification and characterization of genes that control fat deposition in chickens.

J Anim Sci Biotechnol. 2013 Nov 9;4(1):43. [Epub ahead of print]

Claire D, et al.

In this study, Affymetrix GeneChip Chicken Genome Arrays were used to compare gene expression profiles in liver and hypothalamus tissues of fast-growing and slow-growing chickens at eights weeks of age. Four hundred genes in the liver tissues and 220 genes hypothalamus tissues, respectively, were identified to be differentially expressed in fast-growing chickens and slow-growing chickens.

Personalizing the treatment of pediatric medulloblastoma: polo-like kinase 1 as a molecular target in high-Risk children.

Cancer Res. 2013 Nov 7. [Epub ahead of print]

Triscott J, et al.

In this study, pediatric medulloblastomas were subtyped using the NanoString nCounter platform and PLK1 mRNA was assessed. They also screened a library of 129 compounds in clinical trials using a model of pediatric medulloblastoma and determined that PLK1 inhibitors were the most promising class of agents against the growth of medulloblastoma.

DNA methylation profiles in type 1 diabetes twins point to strong epigenetic effects on etiology.

J Autoimmun. 2013 Nov 6. [Epub ahead of print]

Stefan M, et al.

The authors performed DNA methylation profiling in lymphocyte cell lines from 3 monozygotic twin pairs discordant for type 1 diabetes and six monozygotic twin pairs concordant for the disease using the HumanMethylation27 BeadChip. They identified 88 CpG sites displaying significant methylation changes in all T1D-discordant monozygotic twin pairs.