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In Print: Last Week's Microarray Papers of Note: Nov 12, 2013


Identification and characterization of genes that control fat deposition in chickens.

J Anim Sci Biotechnol. 2013 Nov 9;4(1):43. [Epub ahead of print]

Claire D, et al.

In this study, Affymetrix GeneChip Chicken Genome Arrays were used to compare gene expression profiles in liver and hypothalamus tissues of fast-growing and slow-growing chickens at eights weeks of age. Four hundred genes in the liver tissues and 220 genes hypothalamus tissues, respectively, were identified to be differentially expressed in fast-growing chickens and slow-growing chickens.

Personalizing the treatment of pediatric medulloblastoma: polo-like kinase 1 as a molecular target in high-Risk children.

Cancer Res. 2013 Nov 7. [Epub ahead of print]

Triscott J, et al.

In this study, pediatric medulloblastomas were subtyped using the NanoString nCounter platform and PLK1 mRNA was assessed. They also screened a library of 129 compounds in clinical trials using a model of pediatric medulloblastoma and determined that PLK1 inhibitors were the most promising class of agents against the growth of medulloblastoma.

DNA methylation profiles in type 1 diabetes twins point to strong epigenetic effects on etiology.

J Autoimmun. 2013 Nov 6. [Epub ahead of print]

Stefan M, et al.

The authors performed DNA methylation profiling in lymphocyte cell lines from 3 monozygotic twin pairs discordant for type 1 diabetes and six monozygotic twin pairs concordant for the disease using the HumanMethylation27 BeadChip. They identified 88 CpG sites displaying significant methylation changes in all T1D-discordant monozygotic twin pairs.

The Scan

More Boosters for US

Following US Food and Drug Administration authorization, the Centers for Disease Control and Prevention has endorsed booster doses of the Moderna and Johnson & Johnson SARS-CoV-2 vaccines, the Washington Post writes.

From a Pig

A genetically modified pig kidney was transplanted into a human without triggering an immune response, Reuters reports.

For Privacy's Sake

Wired reports that more US states are passing genetic privacy laws.

Science Paper on How Poaching Drove Evolution in African Elephants

In Science this week: poaching has led to the rapid evolution of tuskless African elephants.