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In Print: Last Week's Microarray Papers of Note: Nov 12, 2013


Identification and characterization of genes that control fat deposition in chickens.

J Anim Sci Biotechnol. 2013 Nov 9;4(1):43. [Epub ahead of print]

Claire D, et al.

In this study, Affymetrix GeneChip Chicken Genome Arrays were used to compare gene expression profiles in liver and hypothalamus tissues of fast-growing and slow-growing chickens at eights weeks of age. Four hundred genes in the liver tissues and 220 genes hypothalamus tissues, respectively, were identified to be differentially expressed in fast-growing chickens and slow-growing chickens.

Personalizing the treatment of pediatric medulloblastoma: polo-like kinase 1 as a molecular target in high-Risk children.

Cancer Res. 2013 Nov 7. [Epub ahead of print]

Triscott J, et al.

In this study, pediatric medulloblastomas were subtyped using the NanoString nCounter platform and PLK1 mRNA was assessed. They also screened a library of 129 compounds in clinical trials using a model of pediatric medulloblastoma and determined that PLK1 inhibitors were the most promising class of agents against the growth of medulloblastoma.

DNA methylation profiles in type 1 diabetes twins point to strong epigenetic effects on etiology.

J Autoimmun. 2013 Nov 6. [Epub ahead of print]

Stefan M, et al.

The authors performed DNA methylation profiling in lymphocyte cell lines from 3 monozygotic twin pairs discordant for type 1 diabetes and six monozygotic twin pairs concordant for the disease using the HumanMethylation27 BeadChip. They identified 88 CpG sites displaying significant methylation changes in all T1D-discordant monozygotic twin pairs.

The Scan

Enzyme Involved in Lipid Metabolism Linked to Mutational Signatures

In Nature Genetics, a Wellcome Sanger Institute-led team found that APOBEC1 may contribute to the development of the SBS2 and SBS13 mutational signatures in the small intestine.

Family Genetic Risk Score Linked to Diagnostic Trajectory in Psychiatric Disorders

Researchers in JAMA Psychiatry find ties between high or low family genetic risk scores and diagnostic stability or change in four major psychiatric disorders over time.

Study Questions Existence of Fetal Microbiome

A study appearing in Nature this week suggests that the reported fetal microbiome might be the result of sample contamination.

Fruit Fly Study Explores Gut Microbiome Effects on Circadian Rhythm

With gut microbiome and gene expression experiments, researchers in PNAS see signs that the microbiome contributes to circadian rhythm synchronicity and stability in fruit flies.