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In Print: Last Week's Microarray Papers of Note: Nov 12, 2013


Identification and characterization of genes that control fat deposition in chickens.

J Anim Sci Biotechnol. 2013 Nov 9;4(1):43. [Epub ahead of print]

Claire D, et al.

In this study, Affymetrix GeneChip Chicken Genome Arrays were used to compare gene expression profiles in liver and hypothalamus tissues of fast-growing and slow-growing chickens at eights weeks of age. Four hundred genes in the liver tissues and 220 genes hypothalamus tissues, respectively, were identified to be differentially expressed in fast-growing chickens and slow-growing chickens.

Personalizing the treatment of pediatric medulloblastoma: polo-like kinase 1 as a molecular target in high-Risk children.

Cancer Res. 2013 Nov 7. [Epub ahead of print]

Triscott J, et al.

In this study, pediatric medulloblastomas were subtyped using the NanoString nCounter platform and PLK1 mRNA was assessed. They also screened a library of 129 compounds in clinical trials using a model of pediatric medulloblastoma and determined that PLK1 inhibitors were the most promising class of agents against the growth of medulloblastoma.

DNA methylation profiles in type 1 diabetes twins point to strong epigenetic effects on etiology.

J Autoimmun. 2013 Nov 6. [Epub ahead of print]

Stefan M, et al.

The authors performed DNA methylation profiling in lymphocyte cell lines from 3 monozygotic twin pairs discordant for type 1 diabetes and six monozygotic twin pairs concordant for the disease using the HumanMethylation27 BeadChip. They identified 88 CpG sites displaying significant methylation changes in all T1D-discordant monozygotic twin pairs.

The Scan

Call to Look Again

More than a dozen researchers penned a letter in Science saying a previous investigation into the origin of SARS-CoV-2 did not give theories equal consideration.

Not Always Trusted

In a new poll, slightly more than half of US adults have a great deal or quite a lot of trust in the Centers for Disease Control and Prevention, the Hill reports.

Identified Decades Later

A genetic genealogy approach has identified "Christy Crystal Creek," the New York Times reports.

Science Papers Report on Splicing Enhancer, Point of Care Test for Sexual Transmitted Disease

In Science this week: a novel RNA structural element that acts as a splicing enhancer, and more.