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In Print: Last Week's Microarray Papers of Note: Nov 5, 2013


Genetic ancestry and risk of mortality among US Latinas with breast cancer.
Cancer Res. 2013 Oct 31. [Epub ahead of print]
Fejerman L, et al.

The authors evaluated the association between genetic ancestry and survival after breast cancer diagnosis among 899 Latina women from the San Francisco Bay Area. Genetic ancestry was estimated using an Affymetrix 6.0 array. Their results showed that Individuals with higher Indigenous American ancestry had increased risk of breast cancer-specific mortality.

Pneumococcal bacterial load colonization as a marker of mixed infection in children with alveolar community-acquired pneumonia and respiratory syncytial virus or rhinovirus infection.
Pediatr Infect Dis J. 2013 Nov;32(11):1199-204.
Esposito S, et al.

The authors evaluated whether nasopharyngeal Streptococcus pneumoniae colonization in children with alveolar community-acquired pneumonia and respiratory syncytial virus or rhinovirus infection indicates a mixed lung infection. The nasopharyngeal secretions of 530 children were tested using the Luminex x TAG respiratory virus panel fast assay. They determined that in children with alveolar CAP and RSV or RV infection, the determination of nasopharyngeal pneumococcal bacterial load and identification of the serotypes can contribute to the diagnosis of mixed lung infection.

A genome-wide association study of third molar agenesis in Japanese and Korean populations.
J Hum Genet. 2013 Oct 31. [Epub ahead of print]
Haga S, et al.

This study aimed to identify susceptibility genes associated with third molar agenesis. The authors conducted a genome-wide association study of 149 cases with at least one-third molar agenesis and 338 controls from Japan and Korea using the Illumina HumanOmniExpress BeadChip. They identified three SNPs showing evidence of association.

The Scan

Positive Framing of Genetic Studies Can Spark Mistrust Among Underrepresented Groups

Researchers in Human Genetics and Genomics Advances report that how researchers describe genomic studies may alienate potential participants.

Small Study of Gene Editing to Treat Sickle Cell Disease

In a Novartis-sponsored study in the New England Journal of Medicine, researchers found that a CRISPR-Cas9-based treatment targeting promoters of genes encoding fetal hemoglobin could reduce disease symptoms.

Gut Microbiome Changes Appear in Infants Before They Develop Eczema, Study Finds

Researchers report in mSystems that infants experienced an enrichment in Clostridium sensu stricto 1 and Finegoldia and a depletion of Bacteroides before developing eczema.

Acute Myeloid Leukemia Treatment Specificity Enhanced With Stem Cell Editing

A study in Nature suggests epitope editing in donor stem cells prior to bone marrow transplants can stave off toxicity when targeting acute myeloid leukemia with immunotherapy.