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In Print: Last Week's Microarray Papers of Note: Nov 5, 2013

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Genetic ancestry and risk of mortality among US Latinas with breast cancer.
Cancer Res. 2013 Oct 31. [Epub ahead of print]
Fejerman L, et al.

The authors evaluated the association between genetic ancestry and survival after breast cancer diagnosis among 899 Latina women from the San Francisco Bay Area. Genetic ancestry was estimated using an Affymetrix 6.0 array. Their results showed that Individuals with higher Indigenous American ancestry had increased risk of breast cancer-specific mortality.


Pneumococcal bacterial load colonization as a marker of mixed infection in children with alveolar community-acquired pneumonia and respiratory syncytial virus or rhinovirus infection.
Pediatr Infect Dis J. 2013 Nov;32(11):1199-204.
Esposito S, et al.

The authors evaluated whether nasopharyngeal Streptococcus pneumoniae colonization in children with alveolar community-acquired pneumonia and respiratory syncytial virus or rhinovirus infection indicates a mixed lung infection. The nasopharyngeal secretions of 530 children were tested using the Luminex x TAG respiratory virus panel fast assay. They determined that in children with alveolar CAP and RSV or RV infection, the determination of nasopharyngeal pneumococcal bacterial load and identification of the serotypes can contribute to the diagnosis of mixed lung infection.


A genome-wide association study of third molar agenesis in Japanese and Korean populations.
J Hum Genet. 2013 Oct 31. [Epub ahead of print]
Haga S, et al.

This study aimed to identify susceptibility genes associated with third molar agenesis. The authors conducted a genome-wide association study of 149 cases with at least one-third molar agenesis and 338 controls from Japan and Korea using the Illumina HumanOmniExpress BeadChip. They identified three SNPs showing evidence of association.

The Scan

Germline-Targeting HIV Vaccine Shows Promise in Phase I Trial

A National Institutes of Health-led team reports in Science that a broadly neutralizing antibody HIV vaccine induced bnAb precursors in 97 percent of those given the vaccine.

Study Uncovers Genetic Mutation in Childhood Glaucoma

A study in the Journal of Clinical Investigation ties a heterozygous missense variant in thrombospondin 1 to childhood glaucoma.

Gene Co-Expression Database for Humans, Model Organisms Gets Update

GeneFriends has been updated to include gene and transcript co-expression networks based on RNA-seq data from 46,475 human and 34,322 mouse samples, a new paper in Nucleic Acids Research says.

New Study Investigates Genomics of Fanconi Anemia Repair Pathway in Cancer

A Rockefeller University team reports in Nature that FA repair deficiency leads to structural variants that can contribute to genomic instability.