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In Print: Last Week's Microarray Papers of Note: Oct 29, 2013


Detection of anthrax and other pathogens using a unique liquid array technology.

J Forensic Sci. 2013 Oct 22. [Epub ahead of print]

Schweighardt A, et al.

A bead-based liquid hybridization assay, the Luminex 100, was used to identify four pathogenic bacteria, Bacillus anthracis, Clostridium botulinum, Francisella tularensis subsp. Tularensis, and Yersinia pestis, and several close relatives. All target sequences were detected, even when the minor component was overshadowed by a tenfold excess of the major component.

HLA-B*13:01 and the dapsone hypersensitivity syndrome.

N Engl J Med. 2013 Oct 24;369(17):1620-8.

Zhang F, et al.

The authors used Illumina Human660W-Quad BeadChips to study dapsone hypersensitivity syndrome, a condition that develops in individuals who are prescribed dapsone to treat infections and inflammatory diseases. A genome-wide association studies yielded the variant HLA-B*13:01 as a risk factor for the syndrome. According to the China-based research team. HLA-B*13:01 is present in between 2 and 20 percent of Chinese persons, 1.5 percent of Japanese persons, between 1 and 12 percent of Indians, and between 2 and 4 percent of Southeast Asians but is largely absent in Europeans and Africans.

Optimized laser microdissection of the human ocular surface epithelial regions for microarray studies.

BMC Ophthalmol. 2013 Oct 26;13(1):62. [Epub ahead of print]

Kulkarni B, et al.

The authors collected ocular surface epithelial tissue samples from the limbus, cornea, and conjunctiva of post-mortem cadaver eyes with a laser microdissection technique for use in gene-expression studies with spotted oligonucleotide microarrays and Affymetrix Gene 1.0 ST arrays. They claim their protocol improved the RNA yield of the in situ ocular surface epithelial regions for effective microarray studies.

The Scan

UK Pilot Study Suggests Digital Pathway May Expand BRCA Testing in Breast Cancer

A randomized pilot study in the Journal of Medical Genetics points to similar outcomes for breast cancer patients receiving germline BRCA testing through fully digital or partially digital testing pathways.

Survey Sees Genetic Literacy on the Rise, Though Further Education Needed

Survey participants appear to have higher genetic familiarity, knowledge, and skills compared to 2013, though 'room for improvement' remains, an AJHG paper finds.

Study Reveals Molecular, Clinical Features in Colorectal Cancer Cases Involving Multiple Primary Tumors

Researchers compare mismatch repair, microsatellite instability, and tumor mutation burden patterns in synchronous multiple- or single primary colorectal cancers.

FarGen Phase One Sequences Exomes of Nearly 500 From Faroe Islands

The analysis in the European Journal of Human Genetics finds few rare variants and limited geographic structure among Faroese individuals.