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In Print: Last Week's Microarray Papers of Note: Oct 22, 2013


Arrayed profiling of multiple glycans on whole living cell surface.

Anal Chem. 2013 Oct 15. [Epub ahead of print]

Chen Y, et al.

The authors combined DNA encoding technology with DNA microarray to develop an array-based method for profiling and quantifying multiple glycans on whole living cell surface. They claim that their method possesses "cell surface accessibility, powerful distinguishing capability, fast recognition kinetics, easy miniaturization, and high throughput without need of cell pretreatment or labeling."

Genome-level analyses of Mycobacterium bovis lineages reveal the role of SNPs and antisense transcription in differential gene expression.

BMC Genomics. 2013 Oct 17;14(1):710. [Epub ahead of print]

Golby P, et al.

The authors performed a comprehensive genome-level analyses of four M. bovis strains that encompass the main molecular types of the pathogen circulating in the UK. They used Illumina sequencing technology, a whole-genome amplicon microarray, and a whole-genome tiled oligonucleotide microarray. They found that while these strains show extensive similarities in their genetic make-up and gene expression profiles, they exhibit distinct expression of a subset of genes.

Handy, rapid and multiplex detection of tumor markers based on encoded silica-hydrogel hybrid beads array chip.

Biosens Bioelectron. 2013 Oct 15;48:153-7.

Yang Z, et al.

The authors describe the development and validation of a silica-hydrogel hybrid bead array with photonic encoding. They compared its performance in assessing 50 clinical samples with chemiluminescence immunoassay results. The authors have also developed a cassette-like chip device to "standardize operational processes and benefit automation" in future studies.

The Scan

Sick Newborns Selected for WGS With Automated Pipeline

Researchers successfully prioritized infants with potential Mendelian conditions for whole-genome sequencing or rapid whole-genome sequencing, as they report in Genome Medicine.

Acne-Linked Loci Found Through GWAS Meta-Analysis

Researchers in the European Journal of Human Genetics find new and known acne vulgaris risk loci with a genome-wide association study and meta-analysis, highlighting hair follicle- and metabolic disease-related genes.

Retina Cell Loss Reversed by Prime Editing in Mouse Model of Retinitis Pigmentosa

A team from China turns to prime editing to correct a retinitis pigmentosa-causing mutation in the PDE6b gene in a mouse model of the progressive photoreceptor loss condition in the Journal of Experimental Medicine.

CRISPR Screens Reveal Heart Attack-Linked Gene

Researchers in PLOS Genetics have used CRISPR screens to home in on variants associated with coronary artery disease that affect vascular endothelial function.