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In Print: Last Week's Microarray Papers of Note: Oct 1, 2013


Large-scale genotyping identifies a new locus at 22q13.2 associated with female breast size.

J Med Genet. 2013 Oct;50(10):666-73.

Li J, et al.

To identify common variants that are associated with breast size, the authors conducted a large-scale genotyping association meta-analysis in 7,169 women of European descent across three independent sample collections with digital or screen film mammograms. The samples were genotyped on iCOGS, a custom Illumina iSelect genotyping array. In addition to replicating previous findings, they identified a locus at 22q13 that may be associated with female breast size

Determination of tear and serum inflammatory cytokines in patients with rosacea using multiplex bead technology.

Ocul Immunol Inflamm. 2013 Oct;21(5):351-9.

Topcu-Yilmaz P, et al.

The authors used Luminex bead array technology to compare serum and tear inflammatory and anti-inflammatory cytokine levels of rosacea patients with the healthy controls and to evaluate the correlation of tear cytokine levels with tear function parameters.

Organic trace mineral levels in the first 96-h post-hatch impact growth performance and intestinal gene expression in broiler chicks.

Biol Trace Elem Res. 2013 Sep 28. [Epub ahead of print]

Brennan K, et al.

The objective of this study was to determine the effect of post-hatch dietary mineral supplementation on performance, tissue mineral content, and intestinal gene expression profiles in 21-day-old broiler chicks. Intestinal gene expression profiling was examined using the Affymetrix GeneChip chicken genome array. The authors found that diets fed for the 96-hour, post-hatch had long-term effects on gene expression.

The Scan

Positive Framing of Genetic Studies Can Spark Mistrust Among Underrepresented Groups

Researchers in Human Genetics and Genomics Advances report that how researchers describe genomic studies may alienate potential participants.

Small Study of Gene Editing to Treat Sickle Cell Disease

In a Novartis-sponsored study in the New England Journal of Medicine, researchers found that a CRISPR-Cas9-based treatment targeting promoters of genes encoding fetal hemoglobin could reduce disease symptoms.

Gut Microbiome Changes Appear in Infants Before They Develop Eczema, Study Finds

Researchers report in mSystems that infants experienced an enrichment in Clostridium sensu stricto 1 and Finegoldia and a depletion of Bacteroides before developing eczema.

Acute Myeloid Leukemia Treatment Specificity Enhanced With Stem Cell Editing

A study in Nature suggests epitope editing in donor stem cells prior to bone marrow transplants can stave off toxicity when targeting acute myeloid leukemia with immunotherapy.