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In Print: Last Week's Microarray Papers of Note: Oct 1, 2013


Large-scale genotyping identifies a new locus at 22q13.2 associated with female breast size.

J Med Genet. 2013 Oct;50(10):666-73.

Li J, et al.

To identify common variants that are associated with breast size, the authors conducted a large-scale genotyping association meta-analysis in 7,169 women of European descent across three independent sample collections with digital or screen film mammograms. The samples were genotyped on iCOGS, a custom Illumina iSelect genotyping array. In addition to replicating previous findings, they identified a locus at 22q13 that may be associated with female breast size

Determination of tear and serum inflammatory cytokines in patients with rosacea using multiplex bead technology.

Ocul Immunol Inflamm. 2013 Oct;21(5):351-9.

Topcu-Yilmaz P, et al.

The authors used Luminex bead array technology to compare serum and tear inflammatory and anti-inflammatory cytokine levels of rosacea patients with the healthy controls and to evaluate the correlation of tear cytokine levels with tear function parameters.

Organic trace mineral levels in the first 96-h post-hatch impact growth performance and intestinal gene expression in broiler chicks.

Biol Trace Elem Res. 2013 Sep 28. [Epub ahead of print]

Brennan K, et al.

The objective of this study was to determine the effect of post-hatch dietary mineral supplementation on performance, tissue mineral content, and intestinal gene expression profiles in 21-day-old broiler chicks. Intestinal gene expression profiling was examined using the Affymetrix GeneChip chicken genome array. The authors found that diets fed for the 96-hour, post-hatch had long-term effects on gene expression.

The Scan

Genome Sequences Reveal Range Mutations in Induced Pluripotent Stem Cells

Researchers in Nature Genetics detect somatic mutation variation across iPSCs generated from blood or skin fibroblast cell sources, along with selection for BCOR gene mutations.

Researchers Reprogram Plant Roots With Synthetic Genetic Circuit Strategy

Root gene expression was altered with the help of genetic circuits built around a series of synthetic transcriptional regulators in the Nicotiana benthamiana plant in a Science paper.

Infectious Disease Tracking Study Compares Genome Sequencing Approaches

Researchers in BMC Genomics see advantages for capture-based Illumina sequencing and amplicon-based sequencing on the Nanopore instrument, depending on the situation or samples available.

LINE-1 Linked to Premature Aging Conditions

Researchers report in Science Translational Medicine that the accumulation of LINE-1 RNA contributes to premature aging conditions and that symptoms can be improved by targeting them.