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In Print: Last Week's Microarray Papers of Note: Sep 3, 2013

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An acetylome peptide microarray reveals specificities and deacetylation substrates for all human sirtuin isoforms.
Nat Commun. 2013 Sep 2;4:2327.
Rauh D, et al.

The authors describe a peptide microarray system displaying 6,802 human acetylation sites for the parallel characterization of their modification by deacetylases. Deacetylation data for all seven human sirtuins obtained with this system reveal isoform-specific substrate preferences and deacetylation substrate candidates for all sirtuin isoforms, including Sirt4. The authors claim that their microarray platform enables parallel studies on physiological acetylation sites and the deacetylation data presented provide a resource for the identification of substrates for all human sirtuins.


Accuracy of predicting genomic breeding values for residual feed intake in Angus and Charolais beef cattle.
J Anim Sci. 2013 Aug 26. [Epub ahead of print]
Chen L, et al.

The authors examined the accuracy of predicting genomic breeding values, or GEBV, for residual feed intake based on 522 Angus and 395 Charolais steers genotyped on the Illumina Bovine SNP50 Beadchip for three training population forming strategies: within breed, across breed, and by pooling data from the two breeds. The results showed that the accuracy of the GEBV prediction was the highest when the prediction was within breed and when the validation population had greater genetic relationships with the training population.


Characterization of the genetic profile of five Danish dog breeds.
J Anim Sci. 2013 Aug 29. [Epub ahead of print]
Pertoldi C, et al.

This paper presents results from a genetic characterization of five Danish dog breeds genotyped on the CanineHD BeadChip microarray with 170,000 SNPs. The breeds investigated were Danish Spitz, Danish-Swedish Farm Dog, Broholmer, Old Danish Pointing Dog, and Greenland Dog. They found that observed differences in variation among and within dog breeds may be related to factors such as genetic drift, founder effects, genetic admixture and population bottlenecks.

The Scan

Researchers Develop Polygenic Risk Scores for Dozens of Disease-Related Exposures

With genetic data from two large population cohorts and summary statistics from prior genome-wide association studies, researchers came up with 27 exposure polygenic risk scores in the American Journal of Human Genetics.

US Survey Data Suggests Ancestry Testing Leads Way in Awareness, Use of Genetic Testing Awareness

Although roughly three-quarters of surveyed individuals in a Genetics in Medicine study reported awareness of genetic testing, use of such tests was lower and varied with income, ancestry, and disease history.

Coral Genome Leads to Alternative Amino Acid Pathway Found in Other Non-Model Animals

An alternative cysteine biosynthesis pathway unearthed in the Acropora loripes genome subsequently turned up in sequences from non-mammalian, -nematode, or -arthropod animals, researchers report in Science Advances.

Mosquitos Genetically Modified to Prevent Malaria Spread

A gene drive approach could be used to render mosquitos unable to spread malaria, researchers report in Science Advances.