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In Print: Last Week's Microarray Papers of Note: Sep 3, 2013


An acetylome peptide microarray reveals specificities and deacetylation substrates for all human sirtuin isoforms.
Nat Commun. 2013 Sep 2;4:2327.
Rauh D, et al.

The authors describe a peptide microarray system displaying 6,802 human acetylation sites for the parallel characterization of their modification by deacetylases. Deacetylation data for all seven human sirtuins obtained with this system reveal isoform-specific substrate preferences and deacetylation substrate candidates for all sirtuin isoforms, including Sirt4. The authors claim that their microarray platform enables parallel studies on physiological acetylation sites and the deacetylation data presented provide a resource for the identification of substrates for all human sirtuins.

Accuracy of predicting genomic breeding values for residual feed intake in Angus and Charolais beef cattle.
J Anim Sci. 2013 Aug 26. [Epub ahead of print]
Chen L, et al.

The authors examined the accuracy of predicting genomic breeding values, or GEBV, for residual feed intake based on 522 Angus and 395 Charolais steers genotyped on the Illumina Bovine SNP50 Beadchip for three training population forming strategies: within breed, across breed, and by pooling data from the two breeds. The results showed that the accuracy of the GEBV prediction was the highest when the prediction was within breed and when the validation population had greater genetic relationships with the training population.

Characterization of the genetic profile of five Danish dog breeds.
J Anim Sci. 2013 Aug 29. [Epub ahead of print]
Pertoldi C, et al.

This paper presents results from a genetic characterization of five Danish dog breeds genotyped on the CanineHD BeadChip microarray with 170,000 SNPs. The breeds investigated were Danish Spitz, Danish-Swedish Farm Dog, Broholmer, Old Danish Pointing Dog, and Greenland Dog. They found that observed differences in variation among and within dog breeds may be related to factors such as genetic drift, founder effects, genetic admixture and population bottlenecks.

The Scan

Positive Framing of Genetic Studies Can Spark Mistrust Among Underrepresented Groups

Researchers in Human Genetics and Genomics Advances report that how researchers describe genomic studies may alienate potential participants.

Small Study of Gene Editing to Treat Sickle Cell Disease

In a Novartis-sponsored study in the New England Journal of Medicine, researchers found that a CRISPR-Cas9-based treatment targeting promoters of genes encoding fetal hemoglobin could reduce disease symptoms.

Gut Microbiome Changes Appear in Infants Before They Develop Eczema, Study Finds

Researchers report in mSystems that infants experienced an enrichment in Clostridium sensu stricto 1 and Finegoldia and a depletion of Bacteroides before developing eczema.

Acute Myeloid Leukemia Treatment Specificity Enhanced With Stem Cell Editing

A study in Nature suggests epitope editing in donor stem cells prior to bone marrow transplants can stave off toxicity when targeting acute myeloid leukemia with immunotherapy.