Skip to main content

In Print: Last Week's Microarray Papers of Note: Aug 13, 2013


Targeted resequencing of HIV variants by microarray thermodynamics.
Nucleic Acids Res. 2013 Aug 8. [Epub ahead of print]
Hadiwikarta W, et al.

The authors used DNA microarrays and inputs from hybridization thermodynamics to resequence genomic subsets of HIV. Seven coded clinical samples were analyzed, and the microarray results were found to be concordant with Sanger sequencing data.

Surface engineering for long-term culturing of mesenchymal stem cell microarrays.
Biomacromolecules. 2013 Aug 12;14(8):2675-83.
Rasi Ghaemi S, et al.

The authors describe surface modifications to passivate cell microarrays, in order to adapt the platform to study stem cell behavior over long-term culture periods. The functionalization of glass slides with (3-glycidyloxypropyl) trimethoxysilane enabled covalent anchoring of extracellular matrix proteins on microscale spots printed by a robotic contact printer.

Automated regenerable microarray-based immunoassay for rapid parallel quantification of mycotoxins in cereals.
Anal Bioanal Chem. 2013 Aug;405(20):6405-15.
Oswald S, et al.

This paper describes the development of an automated flow-through multi-mycotoxin immunoassay based on the Munich Chip Reader 3 platform. Using the array, the authors were able to detect in parallel aflatoxins, ochratoxin A, deoxynivalenol, and fumonisins in cereal samples in a competitive indirect immunoassay format.

The Scan

US Supports Patent Waivers

NPR reports that the Biden Administration has announced its support for waiving intellectual property protections for SARS-CoV-2 vaccines.

Vaccines Versus Variants

Two studies find the Pfizer-BioNTech SARS-CoV-2 vaccine to be effective against viral variants, and Moderna reports on booster shots to combat variants.

CRISPR for What Ails You

The Wall Street Journal writes that CRISPR-based therapies could someday be used to treat common conditions like heart attacks.

Nature Papers Review Integration of Single-Cell Assay Data, Present Approach to Detect Rare Variants

In Nature this week: review of ways to integrate data from single-cell assays, and more.