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In Print: Last Week's Microarray Papers of Note: Jul 16, 2013


Single-nucleotide polymorphism microarray-based preimplantation genetic diagnosis is likely to improve the clinical outcome for translocation carriers.
Hum Reprod. 2013 Jul 11. [Epub ahead of print]
Tan Y, Tan K, Zhang S, et al.

The authors aimed to determine whether preimplantation genetic diagnosis for translocation carriers is more effective when done with a SNP array using trophectoderm biopsy and frozen embryo transfer compared with traditional PGD based on fluorescence in situ hybridization using blastomere biopsy and fresh embryo transfer. They found that using arrays improved the clinical pregnancy rate for translocation carriers. The miscarriage rate also slightly decreased.

Mutiscale substrates based on hydrogel-incorporated silicon nanowires for protein patterning and microarray-based immunoassays.
Biosens Bioelectron. 2013 Jul 15;45:129-35.
Han S, Lee S, Hong J, et al.

The authors prepared protein micropatterns on micropatterned nanostructures for potential applications in microarray-based multiplex bioassays. In this paper, they report that the increase in surface area increased the protein loading capacity of the new platform by more than 10 times the capacity of a planar silicon substrate. Immunobinding assays between IgG and anti-IgG and between IgM and anti-IgM that were performed on the micropatterned arrays emitted stronger fluorescent signals and showed higher sensitivity than assays performed on planar silicon substrates.

Automated, high performance, flow-through chemiluminescence microarray for the multiplexed detection of phycotoxins.
Anal Chim Acta. 2013 Jul 17;787:211-8.
Szkola A, Campbell K, Elliott C, et al.

The authors developed a multiplexed immunoassay for the analysis of phycotoxins in shellfish samples. It relies on a regenerable chemiluminescence microarray that is able to analyze automatically three different phycotoxins – domoic acid, okadaic acid, and saxitoxin – in parallel.

The Scan

Positive Framing of Genetic Studies Can Spark Mistrust Among Underrepresented Groups

Researchers in Human Genetics and Genomics Advances report that how researchers describe genomic studies may alienate potential participants.

Small Study of Gene Editing to Treat Sickle Cell Disease

In a Novartis-sponsored study in the New England Journal of Medicine, researchers found that a CRISPR-Cas9-based treatment targeting promoters of genes encoding fetal hemoglobin could reduce disease symptoms.

Gut Microbiome Changes Appear in Infants Before They Develop Eczema, Study Finds

Researchers report in mSystems that infants experienced an enrichment in Clostridium sensu stricto 1 and Finegoldia and a depletion of Bacteroides before developing eczema.

Acute Myeloid Leukemia Treatment Specificity Enhanced With Stem Cell Editing

A study in Nature suggests epitope editing in donor stem cells prior to bone marrow transplants can stave off toxicity when targeting acute myeloid leukemia with immunotherapy.