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In Print: Last Week's Microarray Papers of Note: Jun 18, 2013


Solution-based circuits enable rapid and multiplexed pathogen detection.
Nat Commun. 2013;4:2001.
Lam B, Das J, Holmes RD, et al.

The authors describe solution-based circuits formed on chips that support multiplexed electrochemical sensing. According to the paper, these solution-based circuits switch the information-carrying signal readout channels and eliminate all measurable crosstalk from adjacent, biomolecule-specific microsensors. The authors also report that the chips can be used to classify pathogens at clinically relevant concentrations.

DMET (Drug-Metabolizing Enzymes and Transporters) microarray analysis of colorectal cancer patients with severe 5-fluorouracil-induced toxicity.
Cancer Chemother Pharmacol. 2013 Jun 13. [Epub ahead of print]
Rumiato E, Boldrin E, Amadori A, et al.

The authors used Affymetrix Drug-Metabolizing Enzymes and Transporters Plus GeneChip to identify candidate genetic variants associated with 5-fluorouracil
-induced toxicity. Data obtained suggested that genetic polymorphisms not directly related to 5-FU pharmacokinetics and pharmacodynamics are involved in 5-FU-induced toxicity. They also recommended DMET as a "valid approach to discover new genetic determinants influencing chemotherapy-induced toxicity."

Color-encoded paramagnetic microbead-based direct inhibition triplex flow cytometric immunoassay for ochratoxin A, fumonisins and zearalenone in cereals and cereal-based feed.
Anal Bioanal Chem. 2013 Jun 13. [Epub ahead of print]
Peters J, Thomas D, Boers E, et al.

The authors describe an immunoassay for the simultaneous detection of three mycotoxins in grains that relies on superparamagnetic color-encoded microbeads in combination with two bead-dedicated flow cytometers. In the triplex format, low levels of cross-interactions between the assays occurred. In a preliminary in-house validation, the triplex assay was found to be "reproducible, sensitive, and sufficiently accurate for the quantitative screening."

The Scan

Positive Framing of Genetic Studies Can Spark Mistrust Among Underrepresented Groups

Researchers in Human Genetics and Genomics Advances report that how researchers describe genomic studies may alienate potential participants.

Small Study of Gene Editing to Treat Sickle Cell Disease

In a Novartis-sponsored study in the New England Journal of Medicine, researchers found that a CRISPR-Cas9-based treatment targeting promoters of genes encoding fetal hemoglobin could reduce disease symptoms.

Gut Microbiome Changes Appear in Infants Before They Develop Eczema, Study Finds

Researchers report in mSystems that infants experienced an enrichment in Clostridium sensu stricto 1 and Finegoldia and a depletion of Bacteroides before developing eczema.

Acute Myeloid Leukemia Treatment Specificity Enhanced With Stem Cell Editing

A study in Nature suggests epitope editing in donor stem cells prior to bone marrow transplants can stave off toxicity when targeting acute myeloid leukemia with immunotherapy.