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In Print: Last Week's Microarray Papers of Note: Jun 18, 2013


Solution-based circuits enable rapid and multiplexed pathogen detection.
Nat Commun. 2013;4:2001.
Lam B, Das J, Holmes RD, et al.

The authors describe solution-based circuits formed on chips that support multiplexed electrochemical sensing. According to the paper, these solution-based circuits switch the information-carrying signal readout channels and eliminate all measurable crosstalk from adjacent, biomolecule-specific microsensors. The authors also report that the chips can be used to classify pathogens at clinically relevant concentrations.

DMET (Drug-Metabolizing Enzymes and Transporters) microarray analysis of colorectal cancer patients with severe 5-fluorouracil-induced toxicity.
Cancer Chemother Pharmacol. 2013 Jun 13. [Epub ahead of print]
Rumiato E, Boldrin E, Amadori A, et al.

The authors used Affymetrix Drug-Metabolizing Enzymes and Transporters Plus GeneChip to identify candidate genetic variants associated with 5-fluorouracil
-induced toxicity. Data obtained suggested that genetic polymorphisms not directly related to 5-FU pharmacokinetics and pharmacodynamics are involved in 5-FU-induced toxicity. They also recommended DMET as a "valid approach to discover new genetic determinants influencing chemotherapy-induced toxicity."

Color-encoded paramagnetic microbead-based direct inhibition triplex flow cytometric immunoassay for ochratoxin A, fumonisins and zearalenone in cereals and cereal-based feed.
Anal Bioanal Chem. 2013 Jun 13. [Epub ahead of print]
Peters J, Thomas D, Boers E, et al.

The authors describe an immunoassay for the simultaneous detection of three mycotoxins in grains that relies on superparamagnetic color-encoded microbeads in combination with two bead-dedicated flow cytometers. In the triplex format, low levels of cross-interactions between the assays occurred. In a preliminary in-house validation, the triplex assay was found to be "reproducible, sensitive, and sufficiently accurate for the quantitative screening."

The Scan

Interfering With Invasive Mussels

The Chicago Tribune reports that researchers are studying whether RNA interference- or CRISPR-based approaches can combat invasive freshwater mussels.

Participation Analysis

A new study finds that women tend to participate less at scientific meetings but that some changes can lead to increased involvement, the Guardian reports.

Right Whales' Decline

A research study plans to use genetic analysis to gain insight into population decline among North American right whales, according to CBC.

Science Papers Tie Rare Mutations to Short Stature, Immunodeficiency; Present Single-Cell Transcriptomics Map

In Science this week: pair of mutations in one gene uncovered in brothers with short stature and immunodeficiency, and more.