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In Print: Last Week's Microarray Papers of Note: Jun 18, 2013


Solution-based circuits enable rapid and multiplexed pathogen detection.
Nat Commun. 2013;4:2001.
Lam B, Das J, Holmes RD, et al.

The authors describe solution-based circuits formed on chips that support multiplexed electrochemical sensing. According to the paper, these solution-based circuits switch the information-carrying signal readout channels and eliminate all measurable crosstalk from adjacent, biomolecule-specific microsensors. The authors also report that the chips can be used to classify pathogens at clinically relevant concentrations.

DMET (Drug-Metabolizing Enzymes and Transporters) microarray analysis of colorectal cancer patients with severe 5-fluorouracil-induced toxicity.
Cancer Chemother Pharmacol. 2013 Jun 13. [Epub ahead of print]
Rumiato E, Boldrin E, Amadori A, et al.

The authors used Affymetrix Drug-Metabolizing Enzymes and Transporters Plus GeneChip to identify candidate genetic variants associated with 5-fluorouracil
-induced toxicity. Data obtained suggested that genetic polymorphisms not directly related to 5-FU pharmacokinetics and pharmacodynamics are involved in 5-FU-induced toxicity. They also recommended DMET as a "valid approach to discover new genetic determinants influencing chemotherapy-induced toxicity."

Color-encoded paramagnetic microbead-based direct inhibition triplex flow cytometric immunoassay for ochratoxin A, fumonisins and zearalenone in cereals and cereal-based feed.
Anal Bioanal Chem. 2013 Jun 13. [Epub ahead of print]
Peters J, Thomas D, Boers E, et al.

The authors describe an immunoassay for the simultaneous detection of three mycotoxins in grains that relies on superparamagnetic color-encoded microbeads in combination with two bead-dedicated flow cytometers. In the triplex format, low levels of cross-interactions between the assays occurred. In a preliminary in-house validation, the triplex assay was found to be "reproducible, sensitive, and sufficiently accurate for the quantitative screening."