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In Print: Last Week's Microarray Papers of Note: Jun 18, 2013


Solution-based circuits enable rapid and multiplexed pathogen detection.
Nat Commun. 2013;4:2001.
Lam B, Das J, Holmes RD, et al.

The authors describe solution-based circuits formed on chips that support multiplexed electrochemical sensing. According to the paper, these solution-based circuits switch the information-carrying signal readout channels and eliminate all measurable crosstalk from adjacent, biomolecule-specific microsensors. The authors also report that the chips can be used to classify pathogens at clinically relevant concentrations.

DMET (Drug-Metabolizing Enzymes and Transporters) microarray analysis of colorectal cancer patients with severe 5-fluorouracil-induced toxicity.
Cancer Chemother Pharmacol. 2013 Jun 13. [Epub ahead of print]
Rumiato E, Boldrin E, Amadori A, et al.

The authors used Affymetrix Drug-Metabolizing Enzymes and Transporters Plus GeneChip to identify candidate genetic variants associated with 5-fluorouracil
-induced toxicity. Data obtained suggested that genetic polymorphisms not directly related to 5-FU pharmacokinetics and pharmacodynamics are involved in 5-FU-induced toxicity. They also recommended DMET as a "valid approach to discover new genetic determinants influencing chemotherapy-induced toxicity."

Color-encoded paramagnetic microbead-based direct inhibition triplex flow cytometric immunoassay for ochratoxin A, fumonisins and zearalenone in cereals and cereal-based feed.
Anal Bioanal Chem. 2013 Jun 13. [Epub ahead of print]
Peters J, Thomas D, Boers E, et al.

The authors describe an immunoassay for the simultaneous detection of three mycotoxins in grains that relies on superparamagnetic color-encoded microbeads in combination with two bead-dedicated flow cytometers. In the triplex format, low levels of cross-interactions between the assays occurred. In a preliminary in-house validation, the triplex assay was found to be "reproducible, sensitive, and sufficiently accurate for the quantitative screening."

The Scan

Transcriptomic, Epigenetic Study Appears to Explain Anti-Viral Effects of TB Vaccine

Researchers report in Science Advances on an interferon signature and long-term shifts in monocyte cell DNA methylation in Bacille Calmette-Guérin-vaccinated infant samples.

DNA Storage Method Taps Into Gene Editing Technology

With a dual-plasmid system informed by gene editing, researchers re-wrote DNA sequences in E. coli to store Charles Dickens prose over hundreds of generations, as they recount in Science Advances.

Researchers Model Microbiome Dynamics in Effort to Understand Chronic Human Conditions

Investigators demonstrate in PLOS Computational Biology a computational method for following microbiome dynamics in the absence of longitudinally collected samples.

New Study Highlights Role of Genetics in ADHD

Researchers report in Nature Genetics on differences in genetic architecture between ADHD affecting children versus ADHD that persists into adulthood or is diagnosed in adults.