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In Print: Last Week's Microarray Papers of Note: Jun 11, 2013

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Automated design of paralogue ratio test assays for the accurate and rapid typing of copy number variation.
Bioinformatics. 2013 Jun 6. [Epub ahead of print]
Veal C, Xu H, Reekie K, Free R, et al.

The paralogue ratio test is a method of determining copy number by quantifying the amplification ratio between a target and reference amplicon. The authors designed PRTPrimer, software for automated PRT assay design. In addition to stand-alone software, the website includes a database of pre-designed assays for the human genome at an average spacing of 6 kilobases and a web-interface for custom assay design.


Comprehensive chromosome analysis of blastocysts before implantation using array CGH.
Mol Cytogenet. 2013 Jun 3;6(1):22. [Epub ahead of print]
Chung M, Jeong H, Lee J, et al.

The authors of this study aimed to validate the usefulness of array CGH for the preimplantation genetic screening of embryos at the blastocyst stage of development. A total of 150 blastocysts were biopsied from couples undergoing in vitro fertilization and analyzed using arrays. The authors found that chromosomal microarray analysis provided clinically significant cytogenetic information regarding the frequency and variety of chromosomal abnormalities observed in embryos at the blastocyst stage, and suggested that it is a useful tool for aneuploidy screening in IVF.


A genome-wide association study to detect genetic variation for postpartum dysgalactia syndrome in five commercial pig breeding lines.
Anim Genet. 2013 Jun 7. [Epub ahead of print]
Preissler R, Tetens J, Reiners K, et al.

The aim of this study was to detect loci affecting susceptibility to postpartum dysgalactia syndrome in sows through a genome-wide association approach. The authors genotyped 597 sows using the Illumina PorcineSNP60 BeadChip. A statistically significant genome-wide associated SNP was identified on porcine chromosome 17. Results with moderate significance were detected on chromosomes 13 and 15.

The Scan

Pig Organ Transplants Considered

The Wall Street Journal reports that the US Food and Drug Administration may soon allow clinical trials that involve transplanting pig organs into humans.

'Poo-Bank' Proposal

Harvard Medical School researchers suggest people should bank stool samples when they are young to transplant when they later develop age-related diseases.

Spurred to Develop Again

New Scientist reports that researchers may have uncovered why about 60 percent of in vitro fertilization embryos stop developing.

Science Papers Examine Breast Milk Cell Populations, Cerebral Cortex Cellular Diversity, Micronesia Population History

In Science this week: unique cell populations found within breast milk, 100 transcriptionally distinct cell populations uncovered in the cerebral cortex, and more.