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In Print: Last Week's Microarray Papers of Note: Jun 4, 2013


DNA methylation profiling of placental villi from karyotypically normal miscarriage and recurrent miscarriage.
Am J Pathol. 2013 Jun;182(6):2276-84.
Hanna C, McFadden D, Robinson W

Hypothesizing that aberrant DNA methylation may cause karyotypically normal miscarriage, the authors assessed DNA methylation in first-trimester chorionic villi in chromosomally normal miscarriages from women with recurrent miscarriage, isolated miscarriageand elective terminations using the Illumina Infinium HumanMethylation27 BeadChip array. They determined that altered DNA methylation in the placenta at specific loci, and global dysregulation in specific cases, may contribute to or be a consequence of poor placental function in karyotypically normal miscarriage.

Functional performance of aCGH design for clinical cytogenetics.
Comput Biol Med. 2013 Jul 1;43(6):775-85.
Gambin T, Stankiewicz P, Sykulski M, et al.

The authors of this paper propose a new approach to measure the quality of array CGH designs that measures the robustness of rearrangements detection to the noise. To accomplish this, they implemented the Monte Carlo method for testing noise robustness within DNAcopy software analysis procedure. This framework has been used to assess the functional quality of several array designs.

Gene copy number variations in breast cancer of Sub-Saharan African women.
Breast. 2013 Jun;22(3):295-300.
Ly M, Valent A, Diallo G, et al.

The authors carried out array comparative genomic hybridization profiling of breast cancer samples from Malian women and compared them with samples from American women. Six chromosomal regions were identified with a significant higher rate of copy number alterations. They concluded that breast cancers from African women contain biological differences with those occurring in the US.

The Scan

Could Mix It Up

The US Food and Drug Administration is considering a plan that would allow for the mixing-and-matching of SARS-CoV-2 vaccines and boosters, the New York Times says.

Closest to the Dog

New Scientist reports that extinct Japanese wolf appears to be the closest known wild relative of dogs.

Offer to Come Back

The Knoxville News Sentinel reports that the University of Tennessee is offering Anming Hu, a professor who was acquitted of charges that he hid ties to China, his position back.

PNAS Papers on Myeloid Differentiation MicroRNAs, Urinary Exosomes, Maize Domestication

In PNAS this week: role of microRNAs in myeloid differentiation, exosomes in urine, and more.