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In Print: Last Week's Microarray Papers of Note: May 21, 2013


Genome scan study of prostate cancer in Arabs: identification of three genomic regions with multiple prostate cancer susceptibility loci in Tunisians.
J Transl Med. 2013 May 13;11(1):121.
Shan J, Al-Rumaihi K, Rabah D, et al.

The authors used Affymetrix Genome-Wide Human SNP Array 6.0 to genotype more than 500,000 SNPs in 221 Tunisian individuals.They identified three chromosomal regions, encompassing 14 SNPs, that they claim are significantly associated with prostate cancer risk in the Tunisian population.

Complex tumor genomes inferred from single circulating tumor cells by array-CGH and next-generation sequencing.
Cancer Res. 2013 May 15;73(10):2965-75.
Heitzer E, Auer M, Gasch C, et al.

The authors profiled circulating tumor cells using array comparative genomic hybridization and next-generation sequencing. They found that most mutations initially found only in CTCs were also present at subclonal level in the primary tumors and metastases from the same patient, and argue that CTCs could be used a liquid biopsy in patients with cancer.

The easy road to genome-wide medium density SNP screening in a non-model species: development and application of a 10 K SNP-chip for the house sparrow (Passer domesticus).
Mol Ecol Resour. 2013 May;13(3):429-39.
Hagen I, Billing A, Rønning B, et al.

The authors describe the development of a 10,000-SNP Illumina iSelect HD BeadChip focused on house sparrow. The chip will be used to map quantitative trait loci for fitness-related phenotypic traits in natural populations.

The Scan

Renewed Gain-of-Function Worries

The New York Times writes that the pandemic is renewing concerns about gain-of-function research.

Who's Getting the Patents?

A trio of researchers has analyzed gender trends in biomedical patents issued between 1976 and 2010 in the US, New Scientist reports.

Other Uses

CBS Sunday Morning looks at how mRNA vaccine technology could be applied beyond SARS-CoV-2.

PLOS Papers Present Analysis of Cervicovaginal Microbiome, Glycosylation in Model Archaea, More

In PLOS this week: functional potential of the cervicovaginal microbiome, glycosylation patterns in model archaea, and more.