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In Print: Last Week's Microarray Papers of Note: May 21, 2013


Genome scan study of prostate cancer in Arabs: identification of three genomic regions with multiple prostate cancer susceptibility loci in Tunisians.
J Transl Med. 2013 May 13;11(1):121.
Shan J, Al-Rumaihi K, Rabah D, et al.

The authors used Affymetrix Genome-Wide Human SNP Array 6.0 to genotype more than 500,000 SNPs in 221 Tunisian individuals.They identified three chromosomal regions, encompassing 14 SNPs, that they claim are significantly associated with prostate cancer risk in the Tunisian population.

Complex tumor genomes inferred from single circulating tumor cells by array-CGH and next-generation sequencing.
Cancer Res. 2013 May 15;73(10):2965-75.
Heitzer E, Auer M, Gasch C, et al.

The authors profiled circulating tumor cells using array comparative genomic hybridization and next-generation sequencing. They found that most mutations initially found only in CTCs were also present at subclonal level in the primary tumors and metastases from the same patient, and argue that CTCs could be used a liquid biopsy in patients with cancer.

The easy road to genome-wide medium density SNP screening in a non-model species: development and application of a 10 K SNP-chip for the house sparrow (Passer domesticus).
Mol Ecol Resour. 2013 May;13(3):429-39.
Hagen I, Billing A, Rønning B, et al.

The authors describe the development of a 10,000-SNP Illumina iSelect HD BeadChip focused on house sparrow. The chip will be used to map quantitative trait loci for fitness-related phenotypic traits in natural populations.

The Scan

Pig Organ Transplants Considered

The Wall Street Journal reports that the US Food and Drug Administration may soon allow clinical trials that involve transplanting pig organs into humans.

'Poo-Bank' Proposal

Harvard Medical School researchers suggest people should bank stool samples when they are young to transplant when they later develop age-related diseases.

Spurred to Develop Again

New Scientist reports that researchers may have uncovered why about 60 percent of in vitro fertilization embryos stop developing.

Science Papers Examine Breast Milk Cell Populations, Cerebral Cortex Cellular Diversity, Micronesia Population History

In Science this week: unique cell populations found within breast milk, 100 transcriptionally distinct cell populations uncovered in the cerebral cortex, and more.