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In Print: Last Week's Microarray Papers of Note: May 21, 2013


Genome scan study of prostate cancer in Arabs: identification of three genomic regions with multiple prostate cancer susceptibility loci in Tunisians.
J Transl Med. 2013 May 13;11(1):121.
Shan J, Al-Rumaihi K, Rabah D, et al.

The authors used Affymetrix Genome-Wide Human SNP Array 6.0 to genotype more than 500,000 SNPs in 221 Tunisian individuals.They identified three chromosomal regions, encompassing 14 SNPs, that they claim are significantly associated with prostate cancer risk in the Tunisian population.

Complex tumor genomes inferred from single circulating tumor cells by array-CGH and next-generation sequencing.
Cancer Res. 2013 May 15;73(10):2965-75.
Heitzer E, Auer M, Gasch C, et al.

The authors profiled circulating tumor cells using array comparative genomic hybridization and next-generation sequencing. They found that most mutations initially found only in CTCs were also present at subclonal level in the primary tumors and metastases from the same patient, and argue that CTCs could be used a liquid biopsy in patients with cancer.

The easy road to genome-wide medium density SNP screening in a non-model species: development and application of a 10 K SNP-chip for the house sparrow (Passer domesticus).
Mol Ecol Resour. 2013 May;13(3):429-39.
Hagen I, Billing A, Rønning B, et al.

The authors describe the development of a 10,000-SNP Illumina iSelect HD BeadChip focused on house sparrow. The chip will be used to map quantitative trait loci for fitness-related phenotypic traits in natural populations.

The Scan

RNA Editing in Octopuses Seems to Help Acclimation to Shifts in Water Temperature

A paper in Cell reports that octopuses use RNA editing to help them adjust to different water temperatures.

Topical Compound to Block EGFR Inhibitors May Ease Skin Toxicities, Study Finds

A topical treatment described in Science Translational Medicine may limit skin toxicities seen with EGFR inhibitor therapy.

Dozen Genetic Loci Linked to Preeclampsia Risk in New GWAS

An analysis of genome-wide association study data in JAMA Cardiology finds genetic loci linked to preeclampsia that have ties to blood pressure.

Cancer Survival Linked to Mutational Burden in Pan-Cancer Analysis

A pan-cancer paper appearing in JCO Precision Oncology suggests tumor mutation patterns provide clues for predicting cancer survival that are independent of other prognostic factors.