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In Print: Last Week's Microarray Papers of Note: Oct 21, 2014


Prenatal exposure to maternal cigarette smoking and DNA methylation: epigenome-wide association in a discovery sample of adolescents and replication in an independent cohort at birth through 17 years of age.
Environ Health Perspect. 2014 Oct 17. [Epub ahead of print]
Lee K, et al.

The authors used the Infinium HumanMethylation450K BeadChip to search across 473,395 CpGs for differential DNA methylation associated with prenatal smoke exposure during adolescence in a discovery cohort and at birth, during childhood, and during adolescence in a replication cohort.
Their findings suggest that modifications of DNA methylation associated with prenatal maternal smoking may persist in exposed offspring for many years – at least until adolescence.

Comparative analysis of IgG responses to Plasmodium falciparum MSP1p19 and PF13-DBL1alpha1 using ELISA and a magnetic bead-based duplex assay (MagPix-Luminex) in a Senegalese meso-endemic community.
Malar J. 2014 Oct 17;13(1):410. [Epub ahead of print]
Perraut R, et al.

The authors investigated IgG response against the P. Falciparum merozoite surface protein-1 PfMSP1p19 and the PF13-DBL1alpha1 using an enzyme linked immunosorbant assay and a Luminex assay run on the MagPix platform. Archived plasma samples collected before the rainy season from 217 villagers living in Ndiop, a Senegalese meso-endemic setting, were studied. Based on their findings, they determined that multiplex assessment of antibody responses to a larger panel of antigens with the Luminex technology is warranted.

Same-single-cell analysis using the microfluidic biochip to reveal drug accumulation enhancement by an amphiphilic diblock copolymer drug formulation.
Anal Bioanal Chem. 2014 Oct 15. [Epub ahead of print]
Khamenehfar A, et al.

A microfluidic biochip was used to select single multidrug-resistant cells, and the accumulation of daunoribicin was fluorescently measured in real time on the cells in the absence and presence of MePEG-b-PCL copolymer. The authors said the method allowed them to obtain drug accumulation information faster in comparison to conventional assays.