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In Print: Last Week's Microarray Papers of Note: Sep 16, 2014


Association of non-invasive prenatal testing and chromosomal microarray analysis for prenatal diagnostics.
Gynecol Endocrinol. 2014 Oct;30 Suppl 1:13-6.
Korostelev S, et al.

The authors examined the benefits of combining non-invasive prenatal testing and chromosomal microarray analysis for prenatal diagnostics. Data from 1,968 pregnant women was collected for the study. The authors determined that NIPT is more suitable and efficient for the detection of aneuploidy, but that the test has limitations for the detection of deletions and duplications. They found that using CMA for confirming NIPT findings or as a first test for women with ultrasound abnormalities can detect small imbalances in chromosomes, and concluded that the combination of NIPT and CMA allows a higher prenatal detection of chromosomal abnormalities.

Microarray-based comparative genomic hybridization analysis in neonates with congenital anomalies: detection of chromosomal imbalances.
J Pediatr (Rio J). 2014 Sep 5. [Epub ahead of print]
Dorfman L, et al.

The authors set out to identify chromsomal imbalances associated with congenital anomalies of unknown origin. They genotyped 35 samples using a whole-genome comparative genomic hybridization microarray. They determined that array CGH provided a higher rate of detection of chromosomal anomalies, and argued that this determination is valuable in neonates with congenital anomalies of unknown etiology, or in cases in which karyotype results cannot be obtained.

Identification of QTLs for behavioral reactivity to social separation and humans in sheep using the OvineSNP50 BeadChip.
BMC Genomics. 2014 Sep 9;15(1):778. [Epub ahead of print]
Hazard D, et al.

The authors genotyped 934 Romane lambs using the Illumina OvineSNP50 BeadChip and correlated the data with standard behavioral tests. Their results indicated that in domestic sheep the behavioral responses to social separation and exposure to humans are under polygenic influence. The most relevant quantitative trait loci contained candidate genes previously described to be associated with various emotional and social behaviors in mammals, the authors noted.

The Scan

NFTs for Genome Sharing

Nature News writes that non-fungible tokens could be a way for people to profit from sharing genomic data.

Wastewater Warning System

Time magazine writes that cities and college campuses are monitoring sewage for SARS-CoV-2, an approach officials hope lasts beyond COVID-19.

Networks to Boost Surveillance

Scientific American writes that new organizations and networks aim to improve the ability of developing countries to conduct SARS-CoV-2 genomic surveillance.

Genome Biology Papers on Gastric Cancer Epimutations, BUTTERFLY, GUNC Tool

In Genome Biology this week: recurrent epigenetic mutations in gastric cancer, correction tool for unique molecular identifier-based assays, and more.