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In Print: Last Week's Microarray Papers of Note: Sep 9, 2014


Nightshift work and genome-wide DNA methylation.
Chronobiol Int. 2014 Sep 4:1-10. [Epub ahead of print]
Bhatti P, et al.

The authors used Illumina's Infinium HumanMethylation450 Bead Array to study the negative health effects of shift work, including carcinogenesis, which may be mediated by changes in DNA methylation, particularly in the circadian genes. They compared genome-wide methylation between 65 actively working dayshift workers and 59 actively working nightshift workers in the healthcare industry. Significant differences between nightshift and dayshift workers were found at 16,135 of 473,800 loci. Twenty-one loci located in the circadian genes were also found to be significantly hypomethylated among nightshift workers.

A whole genome association study on meat palatability in Hanwoo.
Asian-Australas J Anim Sci. 2014 Sep;27(9):1219-27.
Hyeong K, et al.

A whole-genome association study was carried out to find quantitative trait loci for sensory evaluation traits in Hanwoo. The carcass samples of 250 Hanwoo steers were collected from the National Agricultural Cooperative Livestock Research Institute in Korea, between 2011 and 2012 and genotyped with the Affymetrix Bovine Axiom Array 640K SNP chip. A total of 1,631 SNPs were detected for color, aroma, tenderness, juiciness, and palatability.

Design of a 9K Illumina BeadChip for polar bears (Ursus maritimus) from RAD and transcriptome sequencing.
Mol Ecol Resour. 2014 Sep 3. [Epub ahead of print]
Malenfant R, et al.

The authors describe the creation of a 9K Illumina Infinium BeadChip for polar bears that will be used to investigate the fine-scale population structure among Canadian polar bears, and the genomic architecture of phenotypic traits in the Western Hudson Bay subpopulation.

The Scan

Machine Learning Helps ID Molecular Mechanisms of Pancreatic Islet Beta Cell Subtypes in Type 2 Diabetes

The approach helps overcome limitations of previous studies that had investigated the molecular mechanisms of pancreatic islet beta cells, the authors write in their Nature Genetics paper.

Culture-Based Methods, Shotgun Sequencing Reveal Transmission of Bifidobacterium Strains From Mothers to Infants

In a Nature Communications study, culture-based approaches along with shotgun sequencing give a better picture of the microbial strains transmitted from mothers to infants.

Microbial Communities Can Help Trees Adapt to Changing Climates

Tree seedlings that were inoculated with microbes from dry, warm, or cold sites could better survive drought, heat, and cold stress, according to a study in Science.

A Combination of Genetics and Environment Causes Cleft Lip

In a study published in Nature Communications, researchers investigate what combination of genetic and environmental factors come into play to cause cleft lip/palate.