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In Print: Last Week’s Microarray Papers of Note

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BAC chromosomal microarray for prenatal detection of chromosome anomalies in fetal ultrasound anomalies: an economic evaluation.
Fetal Diagn Ther. 2014 Jun 13:49-58. [Epub ahead of print]
Hillman S, et al.

The authors assessed the cost of prenatal chromosomal microarrays when performed for structural anomalies on fetal ultrasound scans over conventional techniques. Nine strategies of testing were modeled including combinations of the tests: QF-PCR, G-band karyotyping, CMA, and FISH. They determined that the use of prenatal BAC CMA is not currently cost-effective when compared to other testing strategies.


An antibody array in a multiwell plate format for the sensitive and multiplexed detection of important plant pathogens.
Anal Chem. 2014 Jun 19. [Epub ahead of print]
Charlermroj R, et al.

The authors developed an antibody array in a multiwell plate format to simultaneously detect four crucial plant pathogens: the bacterial fruit blotch bacterium Acidovorax avenae subsp. citrulli, chili vein-banding mottle virus, watermelon silver mottle virus, and melon yellow spot virus. They claimed the antibody array accurately detected plant pathogens in single and multiple detections.


The tissue is the issue: improved methylome analysis from paraffin-embedded tissues by application of the HOPE technique.
Lab Invest. 2014 Jun 16. [Epub ahead of print]
Marwitz S, et al.

The authors compared the influence of fixation on the outcome of Illumina BeadChip methylation analysis. Samples were fixed with formalin and by the non-cross-linking Hepes-glutamic acid buffer mediated organic solvent protection effect, or HOPE, technique. They demonstrated that HOPE fixation is superior to formalin fixation if a subsequent BeadChip analysis of paraffin-embedded sample material is intended.

The Scan

Genome Sequences Reveal Range Mutations in Induced Pluripotent Stem Cells

Researchers in Nature Genetics detect somatic mutation variation across iPSCs generated from blood or skin fibroblast cell sources, along with selection for BCOR gene mutations.

Researchers Reprogram Plant Roots With Synthetic Genetic Circuit Strategy

Root gene expression was altered with the help of genetic circuits built around a series of synthetic transcriptional regulators in the Nicotiana benthamiana plant in a Science paper.

Infectious Disease Tracking Study Compares Genome Sequencing Approaches

Researchers in BMC Genomics see advantages for capture-based Illumina sequencing and amplicon-based sequencing on the Nanopore instrument, depending on the situation or samples available.

LINE-1 Linked to Premature Aging Conditions

Researchers report in Science Translational Medicine that the accumulation of LINE-1 RNA contributes to premature aging conditions and that symptoms can be improved by targeting them.