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In Print: Last Week’s Microarray Papers of Note


BAC chromosomal microarray for prenatal detection of chromosome anomalies in fetal ultrasound anomalies: an economic evaluation.
Fetal Diagn Ther. 2014 Jun 13:49-58. [Epub ahead of print]
Hillman S, et al.

The authors assessed the cost of prenatal chromosomal microarrays when performed for structural anomalies on fetal ultrasound scans over conventional techniques. Nine strategies of testing were modeled including combinations of the tests: QF-PCR, G-band karyotyping, CMA, and FISH. They determined that the use of prenatal BAC CMA is not currently cost-effective when compared to other testing strategies.

An antibody array in a multiwell plate format for the sensitive and multiplexed detection of important plant pathogens.
Anal Chem. 2014 Jun 19. [Epub ahead of print]
Charlermroj R, et al.

The authors developed an antibody array in a multiwell plate format to simultaneously detect four crucial plant pathogens: the bacterial fruit blotch bacterium Acidovorax avenae subsp. citrulli, chili vein-banding mottle virus, watermelon silver mottle virus, and melon yellow spot virus. They claimed the antibody array accurately detected plant pathogens in single and multiple detections.

The tissue is the issue: improved methylome analysis from paraffin-embedded tissues by application of the HOPE technique.
Lab Invest. 2014 Jun 16. [Epub ahead of print]
Marwitz S, et al.

The authors compared the influence of fixation on the outcome of Illumina BeadChip methylation analysis. Samples were fixed with formalin and by the non-cross-linking Hepes-glutamic acid buffer mediated organic solvent protection effect, or HOPE, technique. They demonstrated that HOPE fixation is superior to formalin fixation if a subsequent BeadChip analysis of paraffin-embedded sample material is intended.

The Scan

Positive Framing of Genetic Studies Can Spark Mistrust Among Underrepresented Groups

Researchers in Human Genetics and Genomics Advances report that how researchers describe genomic studies may alienate potential participants.

Small Study of Gene Editing to Treat Sickle Cell Disease

In a Novartis-sponsored study in the New England Journal of Medicine, researchers found that a CRISPR-Cas9-based treatment targeting promoters of genes encoding fetal hemoglobin could reduce disease symptoms.

Gut Microbiome Changes Appear in Infants Before They Develop Eczema, Study Finds

Researchers report in mSystems that infants experienced an enrichment in Clostridium sensu stricto 1 and Finegoldia and a depletion of Bacteroides before developing eczema.

Acute Myeloid Leukemia Treatment Specificity Enhanced With Stem Cell Editing

A study in Nature suggests epitope editing in donor stem cells prior to bone marrow transplants can stave off toxicity when targeting acute myeloid leukemia with immunotherapy.