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PharmaSeq, Hybridon


PharmaSeq, of Monmouth Junction, NJ, has received US Patent Number 6,376,187, “Electronically-indexed solid-phase assay for biomolecules.” This patent covers methods and materials for detecting biomolecules using beads with attached microtransponders that have information relevant to the assay encoded in their memory elements. The patent also describes a device that encodes the information in the transponders and reads the information. A similar patent, Number 6,361,950, was issued March 23rd.


Hybridon of Cambridge, Mass., has received US Patent Number 6,383,752, “Pseudo-cyclic oligonucleobases.” This patent covers a new class of oligonucleotides, “pseudo-cyclic oligonucleotides” (PCOs), that contain two oligonucleotide segments attached through their 3’-3’ or 5’-5’ ends. One segment has some functionality, and another is complementary to the 3’ or 5’ end of the functional segment. This complementary aspect enables PCOs to form intramolecular pseudo-cyclic structures, and to be more stable than conventional oligonucleotides. A fluorophore and quencher molecule attached to the PCOs will fluoresce in the linear configuration and be quenched in the cyclic formation.

The Scan

Genome Sequences Reveal Range Mutations in Induced Pluripotent Stem Cells

Researchers in Nature Genetics detect somatic mutation variation across iPSCs generated from blood or skin fibroblast cell sources, along with selection for BCOR gene mutations.

Researchers Reprogram Plant Roots With Synthetic Genetic Circuit Strategy

Root gene expression was altered with the help of genetic circuits built around a series of synthetic transcriptional regulators in the Nicotiana benthamiana plant in a Science paper.

Infectious Disease Tracking Study Compares Genome Sequencing Approaches

Researchers in BMC Genomics see advantages for capture-based Illumina sequencing and amplicon-based sequencing on the Nanopore instrument, depending on the situation or samples available.

LINE-1 Linked to Premature Aging Conditions

Researchers report in Science Translational Medicine that the accumulation of LINE-1 RNA contributes to premature aging conditions and that symptoms can be improved by targeting them.